192189-63-2Relevant academic research and scientific papers
Synthesis of (S)-Mappicine and mappicine ketone via radical cascade reaction of isonitriles
Josien, Hubert,Curran, Dennis P.
, p. 8881 - 8886 (1997)
(S)-Mappicine (2) and mappicine ketone (1) have been prepared from methylacetoacetate (4) by a strategy featuring a radical cascade reaction of an isonitrile as the key step. The introduction of the hydroxy group of (S)- mappicine occurred with moderate selectivity through asymmetric hydroxylation.
