192209-26-0

Upstream product

• 85920-63-4 5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 638-45-9 1-Iodohexane 
• 100-63-0 phenylhydrazine 
• 1694-31-1 tert-butyl acetoacetate 

Downstream Products

• 1042977-37-6 C₁₆H₂₂N₂O₂ 

Relevant academic research and scientific papers

Solid-phase synthesis of polymer-bound β-ketoesters and their application in the synthesis of structurally diverse pyrazolones

An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydrazine under cyclisation and cleavage from the resin in high purity and good yield.

Solid-phase synthesis of substituted pyrazolones from polymer-bound β-keto esters

Polymer-bound acetoacetate 3 was γ-mono- and γ-dialkylated, as well as α-monoalkylated, to give 6, 9, and 13, respectively. Treatment with hydrazine or substituted hydrazines followed by thermal or acidic cyclizing cleavage yielded the pyrazolones 17a-dd in a purity of >90%.