Solid-phase synthesis of polymer-bound β-ketoesters and their application in the synthesis of structurally diverse pyrazolones

Article abstract of DOI:10.1016/S0960-894X(97)00209-6

An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydrazine under cyclisation and cleavage from the resin in high purity and good yield.