17334-08-6

Usage

Uses

1-Methyl-2-imidazolemethanol is used as intermediates.

InChI:InChI=1/C5H8N2O/c1-7-3-2-6-5(7)4-8/h2-3,8H,4H2,1H3

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 50-00-0 formaldehyd 
• 13750-81-7 N-methyl-2-imidazolcarboxaldehyde 
• 19225-92-4 2-chloromethyl-1-methylimidazole 
• 30148-21-1 ethyl 1-methyl-1H-imidazole-2-carboxylate 

Downstream Products

• 78667-04-6 2-chloromethyl-1-methyl-imidazol hydrochloride 
• 13750-81-7 N-methyl-2-imidazolcarboxaldehyde 
• 100-51-6 benzyl alcohol 
• 1449761-18-5 tert-butyl 2-(diphenylmethyleneamino)-3-(1-methyl-1H-imidazol-2-yl)propanoate 
• 1424382-09-1 C₁₃H₁₃Br₂N₂O₂⁽¹⁺⁾*Br^(1-) 
• 1363404-98-1 C₁₃H₁₃FN₂O₃ 
• 1215229-00-7 N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(1-methyl-1H-imidazol-2-yl)methoxy]-5-(trifluoromethyl)benzamide 
• 1074764-08-1 (3S)-N,N-dibenzyl-5-[(1-methyl-1H-imidazol-2-yl)methoxy]chroman-3-amine 
• 366792-31-6 Zn₄(SC₆H₂(CH(CH₃)2)3)4(OCH₂(C₃N₂H₂)CH₃)3(OCH₃) 
• 1094382-08-7 C₁₂H₁₂N₂O₂ 
• 19225-92-4 2-chloromethyl-1-methylimidazole 
• 861362-06-3 (5-bromo-1-methyl-1H-imidazol-2-yl)methanol 
• 205448-53-9 4-(4-chloro-5-diphenyl-t-butylsilyloxy-2-fluoroanilino)-6-methoxy-7-(1-methylimidazol-2-ylmethoxy)quinoline 
• 87786-06-9 2-(1-methyl-2-imidazolyl)ethylamine 

Relevant academic research and scientific papers

Co(II) complexes derived from (1-methyl-1H-imidazol-2-yl)methanol: Synthesis, characterization, spectroscopic study, DFT/TD-DFT calculations and biological evaluation

We report in this paper, a combined experimental and theoretical study of two new Co(II) complexes [Co(OAc)2(L)2 (1) and CoCl2(L)2 (2)] based on (1-methyl-1H-imidazol-2-yl)methanol (L). The synthetized complexes were characterized by single-crystal X-ray diffraction, FT-IR and UV–Vis. spectroscopy. In complex 1, two molecules of L are coordinated to the Co(II) ion in bidentate mode through the nitrogen and oxygen atoms, displaying a hexa-coordinated compound in a distorted octahedral geometry, while in complex 2, L is ligated to the metal ion in monodentate fashion through the nitrogen atom exhibiting a distorted tetrahedron. The molecular geometries, electronic transitions and vibrational frequencies of the two complexes and L in the ground state were calculated using the global hybrid (B3LYP) and the range separated hybrid (CAM-B3LYP) density functional. The theoretical calculations are in good agreement with the experimental values. The ligand and its Co(II) complexes have been screened and evaluated for their potential as DPPH radical scavengers as well as antimicrobial agents against five pathogenic microorganisms such as Gram-positive and Gram-negative bacteria, a yeast and a fungus. The SAR study revealed that complex 1 exhibited the best antimicrobial effects and higher antioxidant activity than complex 2 and L.

Catalytic phosphorylation using a bifunctional imidazole derived nucleophilic catalyst

A bifunctional catalyst containing a polyether backbone and a nucleophilic imidazole moiety has been prepared that demonstrates cooperative catalysis in the presence of added group 1 and 2 salts for the phosphorylation of alcohols. The Royal Society of Chemistry 2005.

Charge-Compensated Metallacarborane Building Blocks for Conjugation with Peptides

The cobalt bis(dicarbollide) complex [commo-3,3′-Co(1,2-C2B9H11)2]- has captured much attention in biochemical and medical contexts, in particular for the treatment of tumors by boron neutron capture therapy (BNCT). Derivatives of cobalt bis(dicarbollide) are commonly prepared through ring-opening reactions of cyclic oxonium ions, so the corresponding products are usually charged. Furthermore, attempts to incorporate cobalt bis(dicarbollide) into peptides are rare, despite obvious potential advantages. Here the synthesis of an imidazolium-based charge-compensated cobalt bis(dicarbollide) building block, which allows additional modifications with moieties of biochemical relevance, such as monosaccharides, is reported. Furthermore, conjugates of these building blocks with the Y1-receptor-selective derivative of neuropeptide Y ([F7,P34]-NPY) retained excellent response to hY1 receptors found to be overexpressed in breast tumors and metastases.

Synthesis, crystal structure, and SOD-like activity of two copper(II) complexes with hydroxymethyl pendants

Dinuclear and mononuclear copper(II) complexes (1, [Cu2(HL)2(L)2](ClO4)2; 2, [Cu(HL)2(phen)] (ClO4)2, where HL = (N-methyl-2-methylol)imidazole, phen = 1,10-phenanthroline) have been synthesized and characterized by single crystal X-ray diffraction. The SOD-like activity (IC50) of 1 and 2 were measured to be 0.10 ± 0.01 and 0.19 ± 0.01 μM by NBT assay at pH 7.8. The higher SOD activity of 1 could be contributed to the coordination configuration and the labile hydroxymethyl pendants. Electrochemistry and the frontier molecular orbital energies of the complexes were also studied. To mimic the active site of Cu, Zn-SOD, new copper(II) complexes (1, [Cu2(HL)2(L)2](ClO4)2; 2, [Cu(HL)2(phen)](ClO4)2; where HL = (N-methyl-2-methylol)imidazole, phen = 1,10-phenanthroline) have been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. Copper(II) in 1 is four-coordinate by a N2O2 plane with two copper(II) ions bridged with two oxygens from the deprotonated hydroxylmethyl pendants. Each Cu2+ in 2 is coordinated by four nitrogens from two HL and one co-ligand of 1,10-phenanthroline. Electrochemistry of the complexes was studied by cyclic voltammetry. The atomic net charges distribution and frontier molecular orbital energies were obtained by Gaussian 98 program with DFT method at B3LYP/lanl2dz level. The SOD-like activity (IC50) of 1 and 2 were measured as 0.10 ± 0.01 and 0.19 ± 0.01 μM by NBT assay at pH 7.8. The higher SOD activity of 1 could be attributed to the coordination configuration and the labile hydroxymethyl pendants.

Efficient fixation of CO2 into organic carbonates catalyzed by 2-hydroxymethyl-functionalized ionic liquids

Several novel 2-hydroxymethyl-functionalized ILs act as the catalysts for synthesis of cyclic carbonates from CO2 and epoxides without the use of any co-catalysts or organic solvent. Moreover, the 2-hydroxymethyl- functionalized ILs were compatible with base, which combined with K 2CO3 were used as effective catalytic system for green synthesis of dimethyl carbonate from CO2via ethylene carbonate without catalyst separation. Additionally, the mechanistic details of the fixation of CO2 into cyclic carbonate catalyzed by 2-hydroxymethyl-functionalized ILs were also elucidated by density functional theory. The process reported here represents a simple, ecologically safer, cost-effective and energy-saving route to organic carbonates from CO 2.

New Cd(II) complex derived from (1-methylimidazol-2-yl) methanol: Synthesis, crystal structure, spectroscopic study, DFT and TD-DFT calculations, antimicrobial activity and free-radical scavenging capacity

A combined experimental and theoretical study of new complex with a formula of [Cd(Hmim)2(OAc)2], where Hmim stands for (1-methyl-1H-imidazol-2-yl) methanol has been reported. The complex was characterized by single-crystal X-ray diffraction, elemental analysis, FT-IR and UV-vis spectroscopy. The crystal structure of the complex shows that two Hmim and two carboxylate groups are coordinated to the Cd(II) ion in monodentate fashion through the nitrogen and carboxylic oxygen atoms displaying a distorted tetrahedral geometry. Detailed theoretical studies were performed using DFT and TD-DFT calculations, other properties such as chemical bonding analysis (QTAIM, RDG, DOS) have been also carried out and are in agreement with the experimental results. The ligand and its Cd(II) complex have been screened in vitro and evaluated for their potential as DPPH radical scavengers as well as antimicrobial agents against five pathogenic microorganisms such as Gram-positive and Gram-negative bacteria, a yeast and a fungus using the agar diffusion method. The SAR study showed that the free ligand exerts no inhibitory activity, except a moderate activity against the yeast, while the complex exhibits an antimicrobial activity more potent or similar to that of standard drugs against all selected microorganisms, and a moderate to interesting antioxidant potential compared to Vitamin C as control.

PNO ligand containing planar chiral ferrocene and application thereof

The invention discloses a PNO ligand containing planar chiral ferrocene and application thereof. The PNO ligand containing planar chiral ferrocene is a planar chiral ferrocene-containing and phenol-containing PNO ligand as shown in a general formula (I) or (II) which is described in the specification, or a planar chiral ferrocene-containing and aryl-phosphoric-acid-containingPNO ligand containing as shown in a general formula (III) or (IV) which is described in the specification, or a planar chiral ferrocene-containing and carbon-chiral-phenol-containingPNO ligand as shown in a general formula (V) or (VI) which is described in the specification. The invention provides tridentate PNO ligands and processes for their complexation with transition metal salts or transition metal complexes; the introduction of salicylaldehyde and derivatives thereof, which are simple and easy to obtain, enables the ligands to have a bifunctionalization effect, and -OH in a formed catalyst has stronger acidity and is beneficial to combination with N/O in polar double bonds. Therefore, due to the bifunctionalization effect of the catalyst, the interaction between the catalyst and a substrate can be greatly improved, so a reaction can obtain higher catalytic activity and stereoselectivity.

Ionic liquid which has a low cellulose decomposition efficiency

The present invention refers to cellulose decomposition rate of low relates to ionic liquid, the present invention according to ionic liquids compatible ionic liquid and similar or its solubility with cellulose compared to as well as superior, has a remarkably decomposition rate of cellulose disintegration when they dissolve in an unique cellulose therefore, the problem that the components close to by the polyester copolymer. useful. (by machine translation)

Synthesis, crystal structure and antibacterial activity of new highly functionalized ionic compounds based on the imidazole nucleus

Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.

Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use

The present invention pertains generally to the field of therapeutic compounds and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as “PVA compounds”), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.