19227-14-6

Basic information

• Product Name: Benzenecarboximidamide,4-bromo-N-hydroxy-
• Synonyms: Benzamide,p-bromo-, oxime (8CI);4-Bromo-N-hydroxybenzamidine;4-Bromo-N-hydroxybenzenecarboximidamide;4-Bromobenzamidoxime;N'-Hydroxy-4-bromobenzenecarboximidamide;p-Bromobenzamidoxime
• CAS NO: 19227-14-6
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.05
• Product Categories: blocks;Bromides
• Mol File: 19227-14-6.mol
• Article Data: 71

Chemical Properties

• Melting Point: 142-144
• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: /
• Density: 1.68 g/cm³
• PKA: 14.32±0.50(Predicted)
• CAS DataBase Reference: Benzenecarboximidamide,4-bromo-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidamide,4-bromo-N-hydroxy-(19227-14-6)
• EPA Substance Registry System: Benzenecarboximidamide,4-bromo-N-hydroxy-(19227-14-6)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 19227-14-6(Hazardous Substances Data)

Usage

General Description

Benzenecarboximidamide,4-bromo-N-hydroxy- is a chemical compound with the molecular formula C7H7BrN2O. It is commonly known as 4-bromo-1H-benzo[d]imidazole-5-carboximidamide N-hydroxide. Benzenecarboximidamide,4-bromo-N-hydroxy- belongs to the class of organic compounds known as phenylimidazoles. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals. The bromo-substituent on the phenyl ring makes this compound useful in various organic reactions, including nucleophilic substitution and transition-metal catalyzed coupling reactions. Additionally, the hydroxyl group on the imidazole ring enhances its reactivity and stability in certain chemical reactions. Benzenecarboximidamide,4-bromo-N-hydroxy- is known for its wide range of applications in chemistry and pharmaceutical research.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 503027-47-2 N,N'-bis(trimethylsilyl)sulfurdiimide 
• 42811-75-6 p-bromobenzonitrile N-oxide 
• 64-17-5 ethanol 
• 7803-49-8 hydroxylamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 25062-46-8 4-bromobenzaldehyde oxime 
• 100-47-0 benzonitrile 
• 68451-79-6 C₁₅H₁₃BrN₂O₃ 
• 68451-92-3 C₁₄H₁₀BrN₃O₄ 
• 68451-86-5 C₁₄H₁₀BrClN₂O₂ 
• 68451-73-0 C₁₄H₁₁BrN₂O₂ 

Downstream Products

• 118183-92-9 3-(4-bromophenyl)-5-methyl-1,2,4-oxadiazole 
• 132293-61-9 SbCl₅N(OH)C(NH₂)C₆H₄Br 
• 1344149-22-9 3-bromo-N-(2-((((amino(4-bromophenyl)methylene)amino)oxy)carbonyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1442483-73-9 3-bromo-N-(2-(3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1442483-77-3 3-bromo-N-(2-(3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl)-4-bromo-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1342560-61-5 3-(4-bromophenyl)-5-(hydroxymethyl)-1,2,4-oxadiazole 
• 1196958-30-1 3-(4-bromophenyl)-5-(1-hydroxyethyl)-1,2,4-oxadiazole 
• 676131-59-2 3-(4-bromophenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole 
• 364743-34-0 3-(4-bromophenyl)-5-ethyl-1,2,4-oxadiazole 
• 30149-94-1 3-<(3-p-Bromophenyl)-1,2,4-oxadiazol-5-yl>propionic acid 
• 743438-69-9 O-i-propyl-4-bromobenzamidoxime 
• 582300-96-7 O-n-propyl-p-bromobenzamidoxime 

Relevant articles and documents

Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses

This article describes the synthesis and antiviral activity evaluation of new substituted 1,2,4-oxadiazoles containing a bicyclic substituent at position 5 of the heterocycle and O-acylated amidoximes as precursors for their synthesis. New compounds were

Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C?N and S?N bonds formation in a one-pot reaction under

Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists

α: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, we started a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761–0184 that acts as a α7 antagonist. A series of novel piperidine-spirooxadiazole derivatives were subsequently synthesized and evaluated using two-electrode voltage clamp (TEVC) assay in Xenopus oocytes. Lead compounds from two series inhibited α7 with their IC50 values ranging from 3.3 μM to 13.7 μM. Compound B10 exhibited α7 selectivity over other α4β2 and α3β4 nAChR subtypes. The analysis of structure-activity relationship (SAR) provides valuable insights for further development of selective α7 nAChR antagonists.