19227-14-6

Usage

Uses

Used in Pharmaceutical Synthesis:
Benzenecarboximidamide,4-bromo-N-hydroxyis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with improved therapeutic properties. The bromo-substituent on the phenyl ring allows for further functionalization and modification, enabling the synthesis of a wide range of pharmaceutical agents.
Used in Agrochemical Synthesis:
In addition to its applications in pharmaceutical research, Benzenecarboximidamide,4-bromo-N-hydroxyis also utilized in the synthesis of agrochemicals. Its versatile reactivity and structural features make it a valuable component in the development of new agrochemicals with enhanced efficacy and selectivity. Benzenecarboximidamide,4-bromo-N-hydroxycan be used as a starting material for the synthesis of various agrochemicals, including herbicides, insecticides, and fungicides.
Used in Organic Reactions:
Benzenecarboximidamide,4-bromo-N-hydroxyis known for its wide range of applications in organic chemistry. The presence of the bromo-substituent on the phenyl ring makes Benzenecarboximidamide,4-bromo-N-hydroxy- useful in various organic reactions, such as nucleophilic substitution and transition-metal catalyzed coupling reactions. These reactions can be employed to synthesize a variety of organic compounds with diverse applications in various industries.
Used in Chemical Research:
Benzenecarboximidamide,4-bromo-N-hydroxyis a valuable compound for chemical research, particularly in the field of organic synthesis and medicinal chemistry. Its unique structure and reactivity make it an ideal candidate for studying various chemical reactions and mechanisms. Researchers can use Benzenecarboximidamide,4-bromo-N-hydroxy- to explore new synthetic routes, develop novel reaction conditions, and investigate the properties of related compounds.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 68451-73-0 C₁₄H₁₁BrN₂O₂ 
• 68451-86-5 C₁₄H₁₀BrClN₂O₂ 
• 68451-92-3 C₁₄H₁₀BrN₃O₄ 
• 68451-79-6 C₁₅H₁₃BrN₂O₃ 
• 100-47-0 benzonitrile 
• 64-17-5 ethanol 
• 7803-49-8 hydroxylamine 
• 25062-46-8 4-bromobenzaldehyde oxime 
• 1122-91-4 4-bromo-benzaldehyde 
• 42811-75-6 p-bromobenzonitrile N-oxide 
• 503027-47-2 N,N'-bis(trimethylsilyl)sulfurdiimide 

Downstream Products

• 111457-50-2 C₉H₈BrClN₂O₂ 
• 118183-92-9 3-(4-bromophenyl)-5-methyl-1,2,4-oxadiazole 
• 91960-89-3 3,5-bis(4-bromophenyl)-1,2,4-oxadiazole 
• 1445772-43-9 3,5-bis(4-(3-octylthiophen-2-yl)phenyl)-1,2,4-oxadiazole 
• 1445772-38-2 3,5-bis(4-(5-bromo-3-octylthiophen-2-yl)phenyl)-1,2,4-oxadiazole 
• 104849-78-7 C₁₀H₁₁BrN₂O₃ 
• 111457-41-1 3-(4-Bromo-phenyl)-4H-[1,2,4]oxadiazin-5-one 
• 65004-19-5 3-(4-bromophenyl)-5-phenyl[1,2,4]oxadiazole 
• 331989-76-5 3-(4-bromophenyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 582300-96-7 O-n-propyl-p-bromobenzamidoxime 
• 743438-69-9 O-i-propyl-4-bromobenzamidoxime 
• 30149-94-1 3-<(3-p-Bromophenyl)-1,2,4-oxadiazol-5-yl>propionic acid 
• 1161923-76-7 N-phenyl-3-(4-bromophenyl)-1,2,4-thiadiazol-5-amine 
• 694521-68-1 3-(p-bromophenyl)-5-(p-flourophenyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Novel O-acylated amidoximes and substituted 1,2,4-oxadiazoles synthesised from (+)-ketopinic acid possessing potent virus-inhibiting activity against phylogenetically distinct influenza A viruses

This article describes the synthesis and antiviral activity evaluation of new substituted 1,2,4-oxadiazoles containing a bicyclic substituent at position 5 of the heterocycle and O-acylated amidoximes as precursors for their synthesis. New compounds were

Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C?N and S?N bonds formation in a one-pot reaction under

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES

The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.

Entry into (E)-3-(1,2,4-oxadiazol-5-yl)acrylic acids via a one-pot ring-opening/ring-closing/retro-Diels-Alder reaction sequence

A simple and convenient one-pot method is reported for the synthesis of (E)-3-(3-aryl(heteroaryl, alkyl)-1,2,4-oxadiazole-5-yl)acrylic acids utilizing readily accessible or commercially available substituted benzamidoximes and inexpensive exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride. The method is based on the reaction of amidoximes with the anhydride in a basic medium at RT followed by an acid-catalyzed retro-Diels-Alder reaction. The observed stereoselective heterocyclization/retro-Diels-Alder cascade process is suitable for the synthesis of a wide range of substituted (E)-1,2,4-oxadiazole-5-ylacrylic acids featuring electron donating and electron withdrawing groups on the aryl moiety, as well as heteroaryl or alkyl substituents at position 3 of the 1,2,4-oxadiazole ring (42–79%; 15 examples).

Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

Abstract: A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus.

1,2,4-Oxadiazole ring–containing pyridylpyrazole-4-carboxamides: Synthesis and evaluation as novel insecticides of the anthranilic diamide family

Herein, we describe the preparation of pyridylpyrazole-4-carboxamides containing a 1,2,4-oxadiazole ring as novel anthranilic diamide derivatives and compare their insecticidal activities to that of chlorantraniliprole, a well-established potent insectici

Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

The mosquito Aedes aegypti is the vector of arboviruses such as Zika, Chikungunya, dengue and yellow fever. These infectious diseases have a major impact on public health. The unavailability of effective vaccines or drugs to prevent or treat most of these

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

Synthesis of Some Azamacrocycles Bearing 1,2,4-Oxadiazole and 1,2,3-Triazole Moieties

Abstract: A tetraazacrown ether,4,9-di(prop-2-yn-1-yl)-1,4,9,12-tetraazacyclohexadecane-2,11-dione, bearingpropargyl groups on two nitrogens was synthesized starting from1,4,9,12-tetraazacyclohexadecane-2,11-dione and subjected to 1,3-cycloadditionreactio