65004-19-5

Basic information

• Product Name: 3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole
• Synonyms: 3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole
• CAS NO: 65004-19-5
• Molecular Formula: C₁₄H₉BrN₂O
• Molecular Weight: 301.14
• Mol File: 65004-19-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 418.7 °C at 760 mmHg
• Flash Point: 207 °C
• Appearance: /
• Density: 1.465 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(65004-19-5)
• EPA Substance Registry System: 3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(65004-19-5)

Safety Data

• Hazardous Substances Data: 65004-19-5(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-5-phenyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C14H9BrN2O. It belongs to the oxadiazole class of compounds, which are nitrogen-containing heterocycles. This specific compound is a derivative of oxadiazole and is characterized by a bromophenyl group at the 3-position and a phenyl group at the 5-position. It has potential applications in the field of medicinal chemistry and pharmaceuticals, as oxadiazole derivatives have been studied for their various biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. Further research on the chemical and its derivatives may lead to the development of new drugs and therapeutic agents.

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Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Oxidative cyclization of amidoximes and thiohydroximic acids: A facile and efficient strategy for accessing 3,5-disubstituted 1,2,4-oxadiazoles and 1,4,2-oxathiazoles

A facile and practical protocol has been developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and 1,4,2-oxathiazoles through oxidative cyclization of amidoximes and thiohydroximic acids, respectively at room temperature. Use of mild reaction

A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes

Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.