89466-17-1

Basic information

• Product Name: 6-BroMo-5-Methyl-2-pyridinaMine
• Synonyms: 6-BroMo-5-Methyl-2-pyridinaMine;6-Bromo-5-methylpyridin-2-amine;2-Pyridinamine, 6-bromo-5-methyl-
• CAS NO: 89466-17-1
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.03718
• Mol File: 89466-17-1.mol

Chemical Properties

• Melting Point: 96-98 °C
• Boiling Point: 287.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.593±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.96±0.37(Predicted)
• CAS DataBase Reference: 6-BroMo-5-Methyl-2-pyridinaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMo-5-Methyl-2-pyridinaMine(89466-17-1)
• EPA Substance Registry System: 6-BroMo-5-Methyl-2-pyridinaMine(89466-17-1)

Safety Data

• Hazardous Substances Data: 89466-17-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-5-methyl-2-pyridinamine is used as a chemical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Bromo-5-methyl-2-pyridinamine is employed as an intermediate in the production of agrochemicals. It aids in the creation of compounds that can enhance crop protection and contribute to sustainable agriculture practices.
Used in Chemical Product Manufacturing:
6-Bromo-5-methyl-2-pyridinamine is utilized in the manufacturing of a range of chemical products. Its versatility as an intermediate allows for its incorporation into multiple chemical formulations, expanding its applications across various industries.

Upstream product

• 442129-37-5 6-amino-2-chloro-3-methylpyridine 
• 3430-17-9 2-bromo-3-picoline 
• 19230-57-0 2-bromo-3-methylpyridine 1-oxide 

Downstream Products

• 1160221-26-0 Lumacaftor hydrochloride 
• 936727-05-8 Lumacaftor 

Relevant articles and documents

Technological method for preparing 2- amino -6-5-methyl-substituted-pyridine (by machine translation)

The reaction solvent of 2 - the method is reacted in a reaction solvent under the action, of 2 - an, acid anhydride and an acid,binding, agent and an amination reagent under the action. of an acid anhydride and 2 - an acid-binding agent and, an amination reagent, 2 -4 - 93/7, 99.8%, 70%. (by machine translation)

2 - Chloro -3 - methyl -6 - acyl aminopyridine and its preparation and use (by machine translation)

The invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular to the invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular relates to a 2 - chloro - 3 - methyl - 6 - acyl aminopyridine and its preparation and use. The invention provides the following the general formula II of said 2 - chloro - 3 - methyl - 6 - acyl amino pyridine or its pharmaceutically acceptable salt, ester, prodrug or solvate thereof, and [...] fibrosis is an important intermediate of the active ingredient. Through formula II compound represented by the general formula IA or IB obtained compound can be directly used for preparing [...] fibrosis drug. The invention provides general formula IA or IB that the synthesis of the compounds has the following advantages: the security, the method is simple, high yield, it is suitable for industrial production. (by machine translation)

SOLID FORMS OF LUMACAFTOR, ITS SALTS AND PROCESSES THEREOF

Aspects of the present application relate to solid forms of Lumacaftor, its salts and processes thereof. Specific aspects of the present application relate to alternate processes for the preparation of Lumacaftor and intermediates thereof. Present application further relates to the solid forms of Lumacaftor and its salts.

PROCESS FOR PREPARATION OF LUMACAFTOR

The present invention relates to a process for the preparation of amorphous lumacaftor. The present invention relates to a process for the preparation of intermediate 6-amino-2- halo-3-methylpyridine compounds used in the preparation of lumacaftor. The present invention relates to lumacaftor hydrobromide, process for its preparation and conversion thereof to lumacaftor.

Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy

Small heteroaromatic rings are valuable monomers in drug discovery that can enable rapid access to novel and desirable chemical space. Installation of a synthetic handle on a heteroaromatic core may be difficult if steric and electronic factors are not in alignment with the desired transformation. Described are practical routes for the construction of 5-bromo-6-methyl imidazopyrazine (1) as well as 5-bromo and 5-chloro-6-methyl imidazopyridines (2a and 2b), which were developed using electron density surface maps encoded with ionization potential to guide synthetic strategy.