192320-27-7

Usage

Chemical composition

The compound consists of hydrazine and dicarboxylic acid, with a sulfonyl group, a methylphenyl group, and a phenylmethyl ester attached.

Potential applications

It has potential pharmaceutical and medicinal applications due to its structural composition and properties.

Safety precautions

It is important to handle 1,2-Hydrazinedicarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester with care and to follow safety protocols when working with it due to its potentially hazardous nature.

Molecular structure

The compound has a complex molecular structure, with multiple functional groups and a large molecular weight.

Solubility

The compound is likely to be soluble in organic solvents such as ethanol or methanol, but its solubility in water is not specified.

Stability

The stability of the compound under different conditions (e.g., temperature, pH, light exposure) is not specified.

Reactivity

The compound may react with other chemicals, particularly those that can react with its functional groups (e.g., hydrazine, sulfonyl, ester).

Purity

The purity of the compound is not specified, but it is important to use a high-purity grade for research and pharmaceutical applications.

Storage

The compound should be stored in a cool, dry place, away from light and heat, and in a sealed container to prevent degradation or contamination.

Regulatory status

The regulatory status of the compound, including any restrictions on its use or handling, is not specified. It is important to consult relevant guidelines and regulations when working with 1,2-Hydrazinedicarboxylic acid, 1-[(4-methylphenyl)sulfonyl]-2-(phenylmethyl)-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester.

Upstream product

• 200813-53-2 1-tert-butoxycarbonyl-1-tosyl-2-benzyloxycarbonylhydrazine 
• 100-51-6 benzyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 200813-52-1 benzyl 2-tosylhydrazine-1-carboxylate 
• 5331-43-1 N-benzyloxycarbonyl-hydrazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 57699-97-5 N^α-benzyl-N^α-(benzyloxycarbonyl)-N^β-(tert-butyloxycarbonyl)hydrazine 

Relevant academic research and scientific papers

Acidity of Di- and triprotected hydrazine derivatives in dimethyl sulfoxide and aspects of their alkylation

The pKa values in DMSO for 22 di- and triprotected hydrazine NH acids and two monosubstituted hydrazines have been determined using potentiometric titration. The results of density functional theory calculations at the B3LYP/6-311+G** level of gas-phase acidities of a representative selection of mono-, di-, and trisubstituted hydrazines are compared with both the relevant published and novel experimental titration data. In the course of this work, a rough estimation of the pKa value of hydrazine in DMSO (ca. 38.0) has been deduced. For typical triprotected compounds of this kind containing moderately electron-withdrawing carbamate and imidodicarbonate or arenesulfonyl-carbamate functions the pKa values fall in the range 15.1-17.3, whereas for N,N′-diprotected hydrazines with a carbamate and an aromatic sulfonyl group the corresponding values are 12.7-14.5. Several of these triprotected derivatives have recently been applied preparatively in stepwise synthesis of substituted hydrazines using alkyl halides as electrophiles in the presence of a phase transfer catalyst, and a few of them, with varying success, have been examined in model experiments with benzyl alcohol, triphenylphosphine, and diethyl azodicarboxylate in the Mitsunobu reaction. The dependence of the reactivity on the intrinsic acidity of the hydrazines in this reaction is highlighted. Furthermore, the regioselective alkylation of an N,N′-diprotected hydrazine can be rationalized on the basis of the presented data.

A practical reagent for the synthesis of substituted hydrazines

A practical, inexpensive triprotected hydrazine reagent, 2-benzyloxycarbonyl-1 -tert-butoxycarbonyl-1- (4-methylphenylsulfonyl)-hydrazine, 1-Boc-1-Tos-2-Z-hydrazine (2), has been prepared on a 100 pnmol scale and examined with respect to application in st