192370-72-2

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 5470-84-8 4-benzyloxybutanal 

Downstream Products

• 192370-73-3 (2R,3S)-6-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylhexanal 
• 192370-75-5 (3S,5S,6S,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-decanoic acid tert-butyl ester 
• 192370-83-5 (3S,6R,7S)-10-Benzyloxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6-trimethyl-5-oxo-decanoic acid tert-butyl ester 
• 192370-74-4 (5S,6S,7S)-10-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6-trimethyl-3-oxo-decanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

The title compounds have been synthesized in a convergent way by recourse to a Weiler type dianion construction.

Synthesis of epothilones, intermediates thereto, analogues and uses thereof

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.