192512-78-0 Usage
Uses
Used in Organic Synthesis:
1H-Pyrazole-4-carbonitrile, 5-amino-1,3-bis(4-nitrophenyl)is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique functional groups facilitate multiple reaction pathways, contributing to the synthesis of a wide range of chemical products.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Pyrazole-4-carbonitrile, 5-amino-1,3-bis(4-nitrophenyl)is utilized as a key intermediate for the synthesis of pharmaceutical compounds. Its structural features allow for the development of new drugs with potential therapeutic applications.
Used in Pharmaceutical Production:
As an intermediate in pharmaceutical production, 1H-Pyrazole-4-carbonitrile, 5-amino-1,3-bis(4-nitrophenyl)plays a crucial role in the manufacturing process of various drugs. Its presence in the synthesis route enables the production of effective and safe medications.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, 1H-Pyrazole-4-carbonitrile, 5-amino-1,3-bis(4-nitrophenyl)- is used as an intermediate for the synthesis of agrochemicals, such as pesticides and herbicides. Its contribution to the development of these products helps in enhancing crop protection and yield.
Used in Drug Discovery and Development:
1H-Pyrazole-4-carbonitrile, 5-amino-1,3-bis(4-nitrophenyl)is also studied for its potential biological activities and pharmacological properties, making it a valuable compound in drug discovery and development. Its exploration in this field aids in identifying new therapeutic agents and advancing medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 192512-78-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,2,5,1 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 192512-78:
(8*1)+(7*9)+(6*2)+(5*5)+(4*1)+(3*2)+(2*7)+(1*8)=140
140 % 10 = 0
So 192512-78-0 is a valid CAS Registry Number.
192512-78-0Relevant academic research and scientific papers
A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL
Chapman, Eli,Farr, George W.,Furtak, Krystyna,Horwich, Arthur L.
scheme or table, p. 811 - 813 (2009/09/25)
The chaperonin GroEL is a megadalton-sized molecular machine that plays an essential role in the bacterial cell assisting protein folding to the native state through actions requiring ATP binding and hydrolysis. A combination of medicinal chemistry and genetics has been employed to generate an orthogonal pair, a small molecule that selectively inhibits ATPase activity of a GroEL ATP-binding pocket variant. An initial screen of kinase-directed inhibitors identified an active pyrazolo-pyrimidine scaffold that was iteratively modified and screened against a collective of GroEL nucleotide pocket variants to identify a cyclopentyl carboxamide derivative, EC3016, that specifically inhibits ATPase activity and protein folding by the GroEL mutant, I493C, involving a side chain positioned near the base of ATP. This orthogonal pair will enable in vitro studies of the action of ATP in triggering activation of GroEL-mediated protein folding and might enable further studies of GroEL action in vivo. The approach originated for studying kinases by Shokat and his colleagues may thus also be used to study large macromolecular machines.
