192699-03-9

Upstream product

• 192699-02-8 [(S)-1-(2-{4-[3-((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-2-tert-butoxy-ethyl]-carbamic acid benzyl ester 
• 624-18-0 benzene-1,4-diamine hydrochloride 
• 215528-87-3 3-Amino-N-[4-(3-amino-propionylamino)-phenyl]-propionamide 
• 166814-53-5 N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene 

Downstream Products

• 192699-04-0 N,N'-bis[(6-chloropicolinyl)-L-Ser(t-Bu)-β-Ala]-1,4-phenylenediamine 
• 192699-05-1 N,N'-bis[(6-chloropicolinyl)-L-Ser-β-Ala]-1,4-phenylenediamine 

Relevant academic research and scientific papers

Synthesis of a tritium labelled analog of the novel hematoregulatory agent SB 209978

[3H]-SB 209978 (10) was synthesized in 6 steps from phenylene diamine dihydrochloride. A key aspect was the regioselective synthesis of 6-chloropicolinic acid (7). This was condensed with diamine 6 and the resulting product was deprotected to give 9. Palladium catalyzed 3H-hydrogenolysis of the chloropyridine rings gave the final produce 10.