215528-87-3

Upstream product

• 106-50-3 1,4-phenylenediamine 
• 624-18-0 benzene-1,4-diamine hydrochloride 
• 166814-53-5 N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene 

Downstream Products

• 192699-02-8 [(S)-1-(2-{4-[3-((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-2-tert-butoxy-ethyl]-carbamic acid benzyl ester 
• 166814-54-6 [2-benzyloxy-1-(2-{4-[3-(3-benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 192699-04-0 N,N'-bis[(6-chloropicolinyl)-L-Ser(t-Bu)-β-Ala]-1,4-phenylenediamine 
• 192699-05-1 N,N'-bis[(6-chloropicolinyl)-L-Ser-β-Ala]-1,4-phenylenediamine 
• 192699-03-9 (S)-2-Amino-N-(2-{4-[3-((S)-2-amino-3-tert-butoxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethyl)-3-tert-butoxy-propionamide 
• 273928-40-8 C₄₂H₅₄N₈O₈ 
• 166814-76-2 C₄₂H₅₀N₈O₈ 
• 273928-41-9 C₄₀H₅₀N₈O₈ 
• 166814-77-3 C₄₂H₄₆N₈O₈ 
• 166814-83-1 C₄₆H₅₀N₈O₈ 
• 166814-55-7 C₄₄H₄₆N₈O₈ 
• 166814-78-4 (S)-2-Amino-N-(2-{4-[3-((S)-2-amino-3-benzyloxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethyl)-3-benzyloxy-propionamide 
• 166814-66-0 (S)-4-{2-[4-(3-{(S)-4-Benzyloxycarbonyl-2-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-propionylamino)-phenylcarbamoyl]-ethylcarbamoyl}-4-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyric acid benzyl ester 
• 166815-04-9 (S)-4-Amino-4-(2-{4-[3-((S)-2-amino-4-benzyloxycarbonyl-butyrylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-butyric acid benzyl ester 

Relevant academic research and scientific papers

Novel peptidomimetic hematoregulatory compounds

The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure-activity relationships of a peptide SK and F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis of a tritium labelled analog of the novel hematoregulatory agent SB 209978

[3H]-SB 209978 (10) was synthesized in 6 steps from phenylene diamine dihydrochloride. A key aspect was the regioselective synthesis of 6-chloropicolinic acid (7). This was condensed with diamine 6 and the resulting product was deprotected to give 9. Palladium catalyzed 3H-hydrogenolysis of the chloropyridine rings gave the final produce 10.