192699-04-0Relevant articles and documents
Synthesis of a tritium labelled analog of the novel hematoregulatory agent SB 209978
Heerding, Dirk,Saunders, David
, p. 455 - 460 (2007/10/03)
[3H]-SB 209978 (10) was synthesized in 6 steps from phenylene diamine dihydrochloride. A key aspect was the regioselective synthesis of 6-chloropicolinic acid (7). This was condensed with diamine 6 and the resulting product was deprotected to give 9. Palladium catalyzed 3H-hydrogenolysis of the chloropyridine rings gave the final produce 10.