19276-03-0

Basic information

• Product Name: 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL
• Synonyms: BUTTPARK 93\04-05;1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL;1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;1-BENZYL-2-(CHLOROMETHYL)IMIDAZOLE HYDROCHLORIDE;1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCI;1-(benzyl)-2-(chloromethyl)imidazol-1-ium chloride;2-(chloromethyl)-1-(phenylmethyl)imidazol-1-ium chloride;2-(chloromethyl)-1-(phenylmethyl)imidazole hydrochloride
• CAS NO: 19276-03-0
• Molecular Formula: C₁₁H₁₁ClN₂*ClH
• Molecular Weight: 243.13
• Mol File: 19276-03-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 186 °C
• Boiling Point: 333.4°Cat760mmHg
• Flash Point: 155.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000265mmHg at 25°C
• CAS DataBase Reference: 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL(19276-03-0)
• EPA Substance Registry System: 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL(19276-03-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 19276-03-0(Hazardous Substances Data)

Usage

Definition

ChEBI: The hydrochloride salt of 1-benzyl-2-chloromethylimidazole.

InChI:InChI=1/C11H11ClN2.ClH/c12-8-11-13-6-7-14(11)9-10-4-2-1-3-5-10;/h1-7H,8-9H2;1H

Upstream product

• 5272-57-1 1-benzyl-2-(hydroxymethyl)imidazole hydrochloride 
• 4238-71-5 1-benzylimidazole 
• 5376-10-3 1-benzyl-2-(hydroxymethyl)imidazole 

Downstream Products

• 19276-04-1 3-benzyl-2-methyl-3H-imidazole-4-carbonitrile 
• 71239-92-4 2-amino-3-(1-benzyl-1H-imidazol-2-yl)-propionic acid 
• 85102-36-9 1-Benzyl-2-morpholinomethylimidazole 
• 956580-21-5 methyl 1-[(1-benzyl-1H-imidazol-2-yl)methyl]-3-cyclohexyl-2-[2-(hydroxymethyl)phenyl]-1H-indole-6-carboxylate 
• 214353-29-4 S-[(1-Benzyl-1H-imidazol-2-yl)methyl]-N-[4-(4-fluorophenoxy) benzenesulfonyl]-D-penicillamine 
• 1093980-95-0 C₁₁H₁₁N₅ 
• 691361-31-6 3-{7-[(1-benzyl-1H-imidazol-2-yl)methoxy]-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl}-1-[(cyclopropylmethyl)amino]-4-hydroxyquinolin-2(1H)-one 
• 58610-70-1 1-benzyl-2-imidazolylmethyl chloride 
• 21125-22-4 1-benzyl-1H-imidazol-2ylacetonitrile 
• 83219-48-1 Sodium; (1-benzyl-1H-imidazol-2-yl)-methanethiolate 
• 83219-46-9 1,6-bis(N-benzylimidazol-2-yl)-2,5-dithiahexane 
• 83219-47-0 2-(1-Benzyl-1H-imidazol-2-ylmethyl)-isothiourea; hydrochloride 
• 41306-54-1 ethyl 3-(1-benzyl-1H-imidazol-2-yl)propanoate 

Relevant articles and documents

1-SUBSTITUTED-2-(N-PHENYL-N-(PHENYL-METHYL)METHANAMINE)-4,5-DIHYDRO-IMIDAZOLES AND RELATED COMPOUNDS AND THEIR USE IN TREATING CALCIUM OVERLOAD IN BRAIN CELLS

The present patent application discloses compounds of the formula STR1 wherein R 1 is C 1-10 saturated or unsaturated alkyl; or STR2 wherein R'" is H or STR3 R 2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF 3, C. sub.1-6-alkoxy, NO 2, CO 2--C 1-6-alkyl, methyl; benzyl which may be substituted one or more times with halogen, CF 3, C 1-6-alkoxy, NO 2, CO 2--C 1-6-alkyl, methyl; pyridyl; or cyclohexyl;R 3 phenyl which is unsubstituted or substituted one or more times with halogen, CF 3, C 1-6-alkoxy, NO 2, CO 2--C 1-6-alkyl, methyl; naphthyl which may be substituted one or more times with halogen, CF 3, C 1-6-alkoxy, NO 2, CO 2--C 1-6-alkyl, methyl; pyridyl; C 1-6 unsaturated alkyl; furanyl;R 4 is H, C 1-6-alkyl, or benzyl; or STR4 together form STR5 R' and R" are each hydrogen or together form an extra benzo ring; and wherein the dotted line represents an optional extra bond between the two carbon atoms designated α and β, or a pharmaceutically-acceptable addition salt thereof.The compounds are useful as pharmaceuticals, for example in the treatment of Ca overload in brain cells. "

Synthesis of Imidazopyridines from 1-(2-Alkynyl)-2-aminomethylimidazoles

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