58610-70-1Relevant academic research and scientific papers
Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
-
Page/Page column 59-60, (2010/11/28)
The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R1, R2, A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.
Substituted thiazoles as immunoregulants
-
, (2008/06/13)
Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with diphosphoryl pentasulfide. The thiazole derivatives are found to be effective immunoregulants.
SYNTHESIS OF CYANO OXIMES BASED ON AZOLES AND AZINES AND THE EFFECT OF THEIR PROTON-ACCEPTING CHRACTERISTICS ON THE STABILITY OF THE COMPLEXES OF THE LIGANDS WITH THE Fe(II) ION
Chernov'yants, M. S.,Gus'kova, T. V.,Chernoivanova, T. M.,Bagdasarov, K. N.,Tsupak, E. B.
, p. 1993 - 1997 (2007/10/02)
In the series of ligand systems based on ?-deficient azoles and azines with a hydroxyiminocyanomethyl complexing group at the α position to the pyridine-type nitrogen atom the basicity of the heterocyclic nitrogen atom decreases during benzannelation.A comparative assesment was made of the complexing capacity of cyano oximes and the stability of their chelate compounds with the Fe(II) ion.
Metalloenzyme Models. Divalent Metal Ion Catalyzed Hydrolysis of p-Nitrophenyl Picolinate in the Presence of Imidazoles and Pyridines Having Hydroxyl Groups in Their Side Chains
Ogino, Kenji,Shindo, Katsuhiko,Minami, Tooru,Tagaki, Waichiro,Eiki, Toshio
, p. 1101 - 1106 (2007/10/02)
Rate constants for hydrolysis of p-nitrophenyl picolinate at 25 deg C in the pH range 6.5-8.5 were measured in the absence and presence of divalent metal ions (Ni(II), Zn(II), Co(II), Ca, Mg) and substituted imidazoles or pyridines as ligands having alcoholic hydroxyl groups in their side chains. In the presence of either metal ion or ligand, the rate is slow and the pseudo-first-order rate constant (kobsd) increases linearly in a first-order manner with respect to the concentration of metal ion or ligand until it gives the second-order rate constant, kM or kL, respectively. In the presence of both a metal ion (Ni(II) or Zn(II)) and a ligand, rate increase is remarkable for some ligands and the increase in kobsd values constructs saturation curves with respect to increase in either metal ion or ligand concentration. The saturation curves were analyzed based upon rate equations formulated by assuming the formation of 1:1 complex of metal ion and ligands as the catalyst, leading to evaluation of the association constant K for complexes and the second-order rate constant kc for the reaction of complex with substrate. Values of kobsd, kc, and K are dependent greatly upon the structure of ligands and pH. The ligands complexed with Zn(II) ion appear to be simple but highly active models of hydrolytic metalloenzymes.
