192773-96-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 192773-95-8 3-[2-[4-(4-benzyloxyphenyl)butylamino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-ol 
• 192773-94-7 4-(4-benzyloxyphenyl)-N-{2-[2-(3,5-dimethylphenyl)-5-hydroxy-1H-indol-3-yl]ethyl]butyramide 
• 192771-98-5 4-(4-{2-[5-benzyloxy-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenol 
• 192773-92-5 2-[2-[2-(3,5-dimethylphenyl)-5-hydroxy-1H-indol-3-yl]ethyl]isoindole-1,3-dione 
• 192773-93-6 3-(2-aminoethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-ol 
• 192182-34-6 2-[2-[5-benzyloxy-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl]isoindole-1,3-dione 
• 192182-48-2 2-[2-(5-benzyloxy-2-bromo-1H-indol-3-yl)ethyl]isoindole-1,3-dione 
• 53157-45-2 N-[2-(5-benzyloxy-indol-3-yl)-ethyl]-phthalimide 
• 100-39-0 benzyl bromide 
• 6686-26-6 4-(4-benzyloxyphenyl)butyric acid 
• 20776-45-8 5-benzyloxytryptamine 
• 7021-11-6 4-(4-hydroxyphenyl)butanoic acid 

Downstream Products

• 193016-92-1 morpholine-4-carboxylic acid 3-(2-[benzyloxycarbonyl-[4-(4-benzyloxy-phenyl)butyl]amino]-ethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl ester 
• 340809-43-0 piperazine-1-carboxylic acid 3-(2-{benzyloxycarbonyl-[4-(4-benzyloxy-phenyl)-butyl]-amino}-ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl ester 
• 192773-98-1 ethylcarbamic acid 3-(2-[benzyloxycarbonyl-[4-(4-benzyloxyphenyl)butyl]amino]-ethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl ester 

Relevant academic research and scientific papers

SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.

Antagonists of gonadotropin releasing hormone

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.