6686-26-6

Upstream product

• 7021-11-6 4-(4-hydroxyphenyl)butanoic acid 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 19571-34-7 4-(4-benzyloxyphenyl)butyric acid benzyl ester 
• 6686-25-5 4-(4-(benzyloxy)phenyl)-4-oxobutyric acid 
• 946-80-5 (benzyloxy)benzene 
• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 

Downstream Products

• 18093-58-8 3-[3-(p-Benzyloxyphenyl)-propyl]-2-hydroxy-1,4-naphthochinon 
• 130783-40-3 1-benzyloxy-4-(4-hydroxybutyl)benzene 
• 192770-59-5 4-(4-benzyloxy-phenyl)-N-{2-[2-(3,4-dimethoxy-phenyl)-1H-indol-3-yl]-ethyl}-butyramide 
• 69172-21-0 4-(4-Benzyloxyphenyl)butanal 
• 192773-94-7 4-(4-benzyloxyphenyl)-N-{2-[2-(3,5-dimethylphenyl)-5-hydroxy-1H-indol-3-yl]ethyl]butyramide 
• 32263-64-2 7-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 
• 154501-21-0 25,27-bis(4-(4-benzyloxyphenyl)butoxy)-26,28-dihydroxy-p-tert-butylcalix<4>arene 
• 154501-23-2 25,27-bis(4-(4-hydroxyphenyl)butoxy)-26,28-dihydroxy-p-tert-butylcalix<4>arene 
• 154501-19-6 4-(4-benzyloxyphenyl)butyl tosylate 
• 199444-23-0 4-(4-Hydroxy-phenyl)-butyric acid pentachlorophenyl ester 
• 113379-10-5 methyl 6-(4-hydroxyphenyl)hexanoate 
• 6952-35-8 6-(4-hydroxyphenyl)hexanoic acid 

Relevant academic research and scientific papers

An Electrophilic Trifluoromethylthiolation of Silylenol Ethers and β-Naphthols with Diethylaminosulfur Trifluoride and (Trifluoromethyl)trimethylsilane

An efficient and general trifluoromethylthiolation of silylenol ethers and β-naphthols have been accomplished employing the combination of diethylaminosulfur trifluoride (DAST) and (trifluoromethyl)trimethylsilane (CF3TMS) as source of electrophilic trifluoromethylthio moiety for the synthesis of α-trifluoromethylthiolated carbonyl compounds and β-naphthols in good yields. Important features of this method include wide functional group tolerance and use of readily available DAST/CF3TMS. Potential of the methodology was demonstrated via the synthesis of α-trifluoromethylthiolated (+)-4-cholesten-3-one and naphthoquinone. (Figure presented.).

Antagonists of gonadotropin releasing hormone

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.

Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles

A nonpeptidyl GnRH receptor antagonist (1), with a unique 2-arylindole core, was identified through the Merck in-house screening for binding affinity on the rat GnRH receptor. SAR studies directed toward the alkoxy-ethanolamine and 2-aryl groups resulted in a simpler lead structure with improved activity. This compound 50 exhibits a 60-fold improvement in binding activity over our initial lead 1.

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

Kinetics and Mechanism of the Alkaline Hydrolysis of Pentachlorophenyl ω-(p-Hydroxyphenyl)alkanoates

A kinetic study of the alkaline hydrolysis of pentachlorophenyl esters of ω-(p-hydroxyphenyl)alkanoic acids 3 shows that the dissociative route involving a spirodienone intermediate is not a feasible alternative to the normal associative BAC2 pathway.

Head-to-Tail Connected Double Calix[4]arenes

New macrotricyclic compounds consisting of two calix[4]arene substructures connected by aliphatic chains of various length (three to five carbon atoms) between two opposite p-positions and two distal phenolic oxygens have been synthesized. Starting with p-tert-butyl-calix[4]arene, two O-protected phenolic units are attached via ether links in 1,3-position by reaction with the corresponding tosylates. After deprotection, the new calix[4]arene is formed by fragment condensation with 2,6-tobromomethylated 4-alkylphenols. The structure of one example (8c) has been confirmed by single crystal X-ray analysis. Both calixarene parts assume the cone conformation, a molecule of acetonitrile being included in both cavities.