192773-97-0Relevant academic research and scientific papers
SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists
Chu, Lin,Lo, Jane-Ling,Yang, Yi-Tien,Cheng, Kang,Smith, Roy G.,Fisher, Michael H.,Wyvratt, Matthew J.,Goulet, Mark T.
, p. 515 - 517 (2007/10/03)
The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported.
