192804-76-5

Basic information

• Product Name: Benzeneacetic acid, 4-(4-iodobutyl)-, methyl ester
• CAS NO: 192804-76-5
• Molecular Formula: C13H17IO2
• Molecular Weight: 332.181
• Mol File: 192804-76-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 4-(4-iodobutyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-(4-iodobutyl)-, methyl ester(192804-76-5)
• EPA Substance Registry System: Benzeneacetic acid, 4-(4-iodobutyl)-, methyl ester(192804-76-5)

Safety Data

• Hazardous Substances Data: 192804-76-5(Hazardous Substances Data)

Upstream product

• 164931-20-8 methyl 4-(4-hydroxy-1-butyl)phenylacetate 
• 63349-52-0 methyl 4-iodophenylacetate 
• 192804-72-1 methyl 2-(4-(4-hydroxybut-1-yn-1-yl)phenyl)acetate 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 17579-99-6 methyltriphenoxyphosphonium iodide 

Downstream Products

• 192804-78-7 4-(4-iodobutyl)phenylacetic acid 
• 192804-80-1 4-<4-(1H-imidazol-1-yl)butyl>phenylacetic acid 
• 188128-95-2 4-[4-(2-methyl-1H-imidazol-1-yl)butyl]phenylacetic acid 
• 1026444-17-6 [(S)-5-((S)-3-tert-Butoxy-2-{2-[4-(4-imidazol-1-yl-butyl)-phenyl]-acetylamino}-propionylamino)-5-(2-cyclohexyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 1027946-85-5 [(S)-5-[(S)-3-tert-Butoxy-2-(2-{4-[4-(2-methyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-5-(2-cyclohexyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 164931-25-3 (S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-hexanoic acid (2-cyclohexyl-ethyl)-amide 
• 192804-81-2 4-[4-(2-iodo-1H-imidazol-1-yl)butyl]phenylacetic acid 
• 192804-82-3 4-[4-(2-ethyl-1H-imidazol-1-yl)butyl]phenylacetic acid 
• 192804-83-4 4-[4-(2-isopropyl-1H-imidazol-1-yl)butyl]phenylacetic acid 
• 192804-84-5 4-[4-(2-methyl-1H-benzimidazol-1-yl)butyl]phenylacetic acid 
• 1026034-27-4 [(S)-5-[(S)-3-tert-Butoxy-2-(2-{4-[4-(2-iodo-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-5-(2-cyclohexyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 1026688-12-9 [(S)-5-[(S)-3-tert-Butoxy-2-(2-{4-[4-(2-ethyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-5-(2-cyclohexyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 1027559-08-5 [(S)-5-[(S)-3-tert-Butoxy-2-(2-{4-[4-(2-isopropyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-5-(2-cyclohexyl-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 164931-25-3 4-[4-(2-methyl-1H-imidazol-1-yl)butyl]phenylacetyl-D-Ser-D-Lys-(2-cyclohexylethyl)amide 

Relevant articles and documents

Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents

Seryl-lysyl-based peptide and peptidomimetic compounds are described as inhibitors of the enzyme N-myristoyl transferase to provide selective control of the fungal organism Candida albicans. Peptidomimetic compounds of particular interest are those of the formula: STR1 wherein R1 is selected form aminoalkyl, p-aminoalkylphenylalkyl, imidazolylalkylphenylalkyl, 2-alkylimidazolylalkylphenylalkyl, benzimidazolylalkylphenylalkyl and 2-alkylbenzimidazolylalkylphenylalkyl; wherein R2 is selected from hydrido, alkyl, cycloalkyl, akenyl, alkynyl, haloalkyl, benzyl, alkylphenylalkyl, alkoxyphenylalkyl, halophenylalkyl, phenethyl, cycloalkylalkyl, halocycloalkylalkyl, alkylcycloalkylalkyl, alkoxycycloalkylalkyl and naphthylalkyl; wherein Y is selected from carboxylic acid, hydroxamic acid, phosphonic acid and tetrazolyl; or a pharmaceutically-acceptable salt, amide or ester thereof. Compounds of the formula are species-specific inhibitors of C. albicans with little effect on human NMT enzyme and thus would be useful in treating C. albicans fungal infections in humans.

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

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