19282-40-7

Upstream product

• 14063-77-5 (Z)-3-chloro-3-(4-chlorophenyl)acrylaldehyde 
• 623-51-8 ethyl 2-sulfanylacetate 
• 30786-99-3 C₁₀H₉ClOS 
• 5751-83-7 ethyl 5-bromothiophene-2-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 40133-14-0 5-(4-chlorophenyl)thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Programmed Synthesis of Tetra-Aryl Thiophenes with Stepwise, Ester-Controlled Regioselectivity

Herein, we report a modular synthetic route to access tetra-arylated thiophene compounds with four different substituents with programmed chemical control provided by an ester activating/directing group. This method enables the functionalization of indivi

β-Nitroacrylates as Starting Materials of Thiophene-2-Carboxylates Under Continuous Flow Conditions

We report herein a general and efficient continuous flow-based protocol for synthesizing thiophene-2-carboxylates starting from ketal-functionalized β-nitroacrylates. The protocol involves (i) a promoter-free conjugate addition of thioacetic acid to β-nitroacrylates, (ii) a base-induced elimination of nitrous acid, and (iii) a final acid-promoted domino cyclization-aromatization process to afford the title targets. Thanks to the means of the flow chemistry and the use of solid supported systems, the three steps were combined in a whole flow chemical process, by which the products were isolated in good to excellent overall yields (38–88%). (Figure presented.).

Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: A general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields

(Methylthio) acroleins 1a-m were shown to be stable unlike their counterpart the chloroacroleins and their efficacy as 1,3-dielectrophilic properties have now been examined successfully in this work. They are shown to react with ethyl thioglycolate in the

NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I where R1, R1a, R1b, A, R3, R4, R5, R5b and R6 are as defined herein.

Microwave assisted synthesis of 5-arylthiophene-2-carboxylates

A simple and rapid method for the synthesis of 5-Aryl-thiophene-2- carboxylates 3 has been developed by the condensation of β-chlorovinyl aldehydes 1 with mercaptoacetic acid esters 2 under microwave irradiation conditions.