40133-14-0

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Chlorophenyl)thiophene-2-carboxylic acid is used as a building block for creating new drugs and bioactive molecules in the field of medicinal chemistry. Its unique structure allows for the development of compounds with potential therapeutic applications.
Used in Agrochemical Industry:
5-(4-Chlorophenyl)thiophene-2-carboxylic acid is used in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Organic Compounds Synthesis:
5-(4-Chlorophenyl)thiophene-2-carboxylic acid is utilized in the synthesis of various organic compounds, expanding the range of chemical products available for different applications.
Used in Specialty Chemicals and Materials Production:
5-(4-Chlorophenyl)thiophene-2-carboxylic acid may also have uses in the production of specialty chemicals and materials, showcasing its versatility in various industries.

InChI:InChI=1/C11H7ClO2S/c12-8-3-1-7(2-4-8)9-5-6-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 51335-90-1 1-[5-(4-chlorophenyl)thiophen-2-yl]ethan-1-one 
• 116016-54-7 2,2,-dithiobis<5-(p-chlorophenyl)-2,4-pentanedioic acid> 
• 38401-71-7 5-(4-chlorophenyl)thiophene-2-carboxaldehyde 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 124-38-9 carbon dioxide 
• 19282-40-7 ethyl 5-(4-chlorophenyl) thiophene-2-carboxylate 
• 106-47-8 4-chloro-aniline 
• 116016-37-6 5-(p-chlorocinnamylidene)rhodanine 
• 116016-49-0 2-mercapto-5-(p-chlorophenyl)-2,4-pentadienoic acid 
• 1075-77-0 4-chlorocinnamaldehyde 
• 108-90-7 chlorobenzene 

Downstream Products

• 649569-56-2 methyl 5-(4-chlorophenyl)thiophene-2-carboxylate 
• 921592-97-4 5-(4-chlorophenyl)-3-formylthiophene-2-carboxylic acid 
• 897661-99-3 2-(4-chlorophenyl)thieno[2,3-d]pyridazin-7(6H)-one 

Relevant academic research and scientific papers

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of 4-phenyl-4,5-dihydrooxazole derivatives were designed and synthesized. It was especially encouraging that compound 22a displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound 22a could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound 22a was improved significantly, with the half-life of 70.5 min. Compound 22a was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound 22a exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound 22a is worthy of further study.

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.

INDAZOLE DERIVATIVES USEFUL AS MELANIN CONCENTRATING RECEPTOR LIGANDS

The present invention relates to novel compounds, in particular, novel indazole that may be used as melanin concentrating hormone receptor ligands, methods of preparing such compounds, compositions containing such compounds, and methods of using such compounds to treat MCH related disorders.

NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I where R1, R1a, R1b, A, R3, R4, R5, R5b and R6 are as defined herein.

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.

Synthesis of Unsymmetrical Arylthiophenes and Bithienyls via Oxidative Cyclization of 1,3-Butadiene-1-thiols

Oxidative cyclization of 2-mercapto-5-aryl-2,4-pentanedienoic acids with iodine produced the respective 5-aryl-2-thenoic acids.The method was also suitable for the synthesis of unsymmetrical substituted 2,2,-bithienyls, and 2,3'-bithienyls.The synthesis o