40133-14-0

Basic information

• Product Name: 5-(4-Chlorophenyl)thiophene-2-carboxylic acid
• Synonyms: 5-(4-Chlorophenyl)thiophene-2-carboxylicacid
• CAS NO: 40133-14-0
• Molecular Formula: C₁₁H₇ClO₂S
• Molecular Weight: 238.69
• Mol File: 40133-14-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 418.7°Cat760mmHg
• Flash Point: 207°C
• Appearance: /
• Density: 1.415g/cm³
• Vapor Pressure: 9.24E-08mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-Chlorophenyl)thiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chlorophenyl)thiophene-2-carboxylic acid(40133-14-0)
• EPA Substance Registry System: 5-(4-Chlorophenyl)thiophene-2-carboxylic acid(40133-14-0)

Safety Data

• Hazardous Substances Data: 40133-14-0(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)thiophene-2-carboxylic acid is a chemical compound that belongs to the class of thiophene carboxylic acids. It has a molecular formula C11H7ClO2S and a molecular weight of 238.69 g/mol. 5-(4-Chlorophenyl)thiophene-2-carboxylic acid is characterized by a thiophene ring with a carboxylic acid group and a chlorine-substituted phenyl group attached to it. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It has potential applications in the field of medicinal chemistry, specifically as a building block for creating new drugs and bioactive molecules. Additionally, it may also have uses in the production of specialty chemicals and materials. Overall, 5-(4-Chlorophenyl)thiophene-2-carboxylic acid is a versatile compound with diverse applications in various industries.

InChI:InChI=1/C11H7ClO2S/c12-8-3-1-7(2-4-8)9-5-6-10(15-9)11(13)14/h1-6H,(H,13,14)

Upstream product

• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 124-38-9 carbon dioxide 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 19282-40-7 ethyl 5-(4-chlorophenyl) thiophene-2-carboxylate 
• 106-47-8 4-chloro-aniline 
• 116016-37-6 5-(p-chlorocinnamylidene)rhodanine 
• 116016-49-0 2-mercapto-5-(p-chlorophenyl)-2,4-pentadienoic acid 
• 1075-77-0 4-chlorocinnamaldehyde 
• 108-90-7 chlorobenzene 
• 38401-71-7 5-(4-chlorophenyl)thiophene-2-carboxaldehyde 
• 116016-54-7 2,2,-dithiobis<5-(p-chlorophenyl)-2,4-pentanedioic acid> 
• 51335-90-1 1-[5-(4-chlorophenyl)thiophen-2-yl]ethan-1-one 

Downstream Products

• 921592-97-4 5-(4-chlorophenyl)-3-formylthiophene-2-carboxylic acid 
• 649569-56-2 methyl 5-(4-chlorophenyl)thiophene-2-carboxylate 
• 897661-99-3 2-(4-chlorophenyl)thieno[2,3-d]pyridazin-7(6H)-one 

Relevant articles and documents

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of 4-phenyl-4,5-dihydrooxazole derivatives were designed and synthesized. It was especially encouraging that compound 22a displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound 22a could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound 22a was improved significantly, with the half-life of 70.5 min. Compound 22a was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound 22a exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound 22a is worthy of further study.

Direct carboxylation of thiophenes and benzothiophenes with the aid of EtAlCl2

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NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I where R1, R1a, R1b, A, R3, R4, R5, R5b and R6 are as defined herein.