192826-57-6

Basic information

• Product Name: 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethylphenyl)ethan-1-ol
• Synonyms: 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethylphenyl)ethan-1-ol
• CAS NO: 192826-57-6
• Molecular Weight: 320.234
• Mol File: 192826-57-6.mol

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethylphenyl)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethylphenyl)ethan-1-ol(192826-57-6)
• EPA Substance Registry System: 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethylphenyl)ethan-1-ol(192826-57-6)

Safety Data

• Hazardous Substances Data: 192826-57-6(Hazardous Substances Data)

Upstream product

• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 75-46-7 trifluoromethan 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 96235-99-3 Toluene-4-sulfonic acid 2,2,2-trifluoro-1-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl ester 

Relevant articles and documents

Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS

PROBLEM TO BE SOLVED: To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals. SOLUTION: This invention relates to a method for producing trifluoromethyl group-containing alcohols expressed by a formula (2), comprising: making carbonyl compounds expressed by a formula (1) react with trifluoromethane in an organic solvent in the presence of polyvalent ethers and potassium tert-butoxide, or kalium hexamethyldisilazide. (R1 and R2 are each independently a phenyl group etc.; R2 may combine with R1, to form a ring, and both R1 and R2 are not hydrogen atoms). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

The trifluoromethylation of carbonyl compounds is accomplished by the stable (trifluoromethyl)zinc reagent generated and then isolated from CF3I and ZnEt2, which can be utilized as a trifluoromethyl anion source (CF3-). The reaction proceeds smoothly with diamine as a ligand and ammonium salt as an initiator, providing the corresponding trifluoromethylated alcohol products. Moreover, the (trifluoromethyl)zinc reagent can also be employed as a difluorocarbene source (:CF2) not only for gem-difluoroolefination of carbonyl compounds with phosphine but also for gem-difluorocyclization of alkenes or alkynes via the thermal decomposition, respectively.

Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers

A new strategy towards [18F]trifluoromethyl-containing compounds is developed. [18F]trifluoromethane is synthesised in a fast and efficient manner and subsequently used in the reaction with aldehydes and ketones forming [18/sup

SOLVOLYTIC STUDIES OF THE HIGHLY CROWDED 1-ARYL-1-PHENYL-1-(TRIFLUOROMETHYL)METHYL BR0MIDE AND TOSYLATES

In the titled system the remarkably high tosylate/bromide solvolysis rate ratio of 1.56E6:1 indicates a highly strained ground state, and the reverse order of reactivity for substrate having l-(4-trifluoromethyl)phenyl vs. that having 1-(3-trifluoromethyl