192870-65-8

Usage

General Description

1,4-Dioxaspiro[4.5]decane, 8-(2-propenyloxy)- is a chemical compound that is also known as 8-(2-propenyloxy)-1,4-dioxaspiro[4.5]decane. It belongs to the class of organic compounds known as spiroketals. 1,4-Dioxaspiro[4.5]decane, 8-(2-propenyloxy)- has a cyclic structure with two oxygen atoms bridging the two alkyl groups. It is used in various industrial applications, including as a fragrance ingredient and as a component in the production of pharmaceuticals and agrochemicals. The chemical properties and potential hazards of 1,4-Dioxaspiro[4.5]decane, 8-(2-propenyloxy)- are vital considerations for its safe handling and usage in these applications.

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 106-95-6 allyl bromide 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 192870-66-9 4-(allyloxy)cyclohexanone 
• 1070779-89-3 C₉H₁₆O₃ 

Relevant academic research and scientific papers

MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

NEW GALLIUM BISAMINOTHIOLATE COMPLEXES FOR MYOCARDIAL IMAGING

The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof; wherein A1, A2 and A3 are the same or different cycloalkyl, wherein at least one of A1, A2 or A3 is substituted. R1 through R6 are independently hydrogen or alkyl, R7 and R8 are independently hydrogen or alkyl and RP is hydrogen or sulfhydryl protecting group. This invention is also directed to complexes, wherein said compounds chelate radioactive metal ions, such as Gallium. The complexes of the rpesent invention are useful as myocardial perfusion imaging agents.

New bioorganic reagents: Evolved cyclohexanone monooxygenase - Why is it more selective?

Four mutants of the cyclohexanone monooxygenase (CHMO) evolved as catalysts for Baeyer-Villiger oxidation of 4-hydroxycyclohexanone were investigated as catalysts for a variety of 4-substituted and 4,4-disubstituted cyclohexanones. Several excellent catalytic matches (mutant/substrate) were identified. The most important, however, is the finding that, in a number of cases, a mutant with a single exchange, Phe432Ser, was shown to be as robust and more selective as a catalyst than the wild-type CHMO. All biotransformations were performed on a laboratory scale, allowing full characterization of the products. The absolute configurations of two products were established. A model suggesting a possible role of the 432 serine residue in enantioselectivity control is proposed.

1-phenyl-2-dimenthylaminomethyl-cyclohexan-1-ol compounds as pharmaceutical active ingredients

1-phenyl-2-dimethylaminomethyl-cyclohexan-1-ol compounds, methods of preparing them and the use of these compounds in drugs are described.