192943-54-7Relevant academic research and scientific papers
Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1
Flynn, Autumn R.,Mays, Suzanne G.,Ortlund, Eric A.,Jui, Nathan T.
, p. 1051 - 1056 (2018)
The orphan nuclear receptor Liver Receptor Homologue-1 (LRH-1) is an emerging drug target for metabolic disorders. The most effective known LRH-1 modulators are phospholipids or synthetic hexahydropentalene compounds. While both classes have micromolar ef
Mechanistic Studies on the Organocatalytic α-Chlorination of Aldehydes: The Role and Nature of Off-Cycle Intermediates
Ponath, Sebastian,Menger, Martina,Grothues, Lydia,Weber, Manuela,Lentz, Dieter,Strohmann, Carsten,Christmann, Mathias
supporting information, p. 11683 - 11687 (2018/09/10)
Herein we report the isolation and characterization of aminal intermediates in the organocatalytic α-chlorination of aldehydes. These species are stable covalent ternary adducts of the substrate, the catalyst and the chlorinating reagent. NMR-assisted kinetic studies and isotopic labeling experiments with the isolated intermediate did not support its involvement in downstream stereoselective processes as proposed by Blackmond. By tuning the reactivity of the chlorinating reagent, we were able to suppress the accumulation of rate-limiting off-cycle intermediates. As a result, an efficient and highly enantioselective catalytic system with a broad functional group tolerance was developed.
Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH-insensitive Inhibitory Effects on the Mitochondrial ADP/ATP Carrier
Yamamoto, Atsushi,Hasui, Keisuke,Matsuo, Hiroshi,Okuda, Katsuhiro,Abe, Masato,Matsumoto, Kenji,Harada, Kazuki,Yoshimura, Yuya,Yamamoto, Takenori,Ohkura, Kazuto,Shindo, Mitsuru,Shinohara, Yasuo
, p. 1304 - 1322 (2015/10/28)
Bongkrekic acid, isolated from Burkholderia cocovenenans, is known to specifically inhibit the mitochondrial ADP/ATP carrier. However, the manner of its interaction with the carrier remains elusive. In this study, we tested the inhibitory effects of 17 bo
A concise diastereoselective approach to the left-hand side of batzelladine A
Davies, Christopher D.,Elliott, Mark C.,Hill-Cousins, Joseph,Khan, Misbah-Ul A.,Maqbool, Tahir,Wood, John L.
scheme or table, p. 2028 - 2032 (2009/04/07)
A highly diastereoselective three-component coupling reaction has been used in a concise approach to the left-hand side of batzelladine A. The stereoselectivity of this reaction, along with related observations described herein, provides insight into the mechanism of this reaction.
Cyclative cleavage via solid-phase supported stabilized sulfur ylides: Synthesis of macrocyclic lactones
La Porta, Elena,Piarulli, Umberto,Cardullo, Francesca,Paio, Alfredo,Provera, Stefano,Seneci, Pierfausto,Gennari, Cesare
, p. 761 - 766 (2007/10/03)
A new synthesis of macrolactones bearing a cyclopropyl ring condensed to the macrocycle is reported via a cyclization-release strategy making use of solid-phase supported stabilized sulfur ylides.
A mild and convenient deprotection of 4-phenyl 1,3-dioxolane derivatives under catalytic hydrogenation
Chandrasekhar,Muralidhar,Sarkar, Sanjita
, p. 2691 - 2694 (2007/10/03)
A new procedure for deprotection of 4-phenyl 1,3-dioxolanes to liberate free carbonyl compound under catalytic hydrogenation conditions is described.
