19310-98-6

Usage

Uses

Used in Pharmaceutical Industry:
8-Methylnaphthalene-1-carboxylic acid is used as a building block for the synthesis of various organic compounds and pharmaceuticals, due to its versatile chemical structure and reactivity.
Used in Drug Development:
8-Methylnaphthalene-1-carboxylic acid is used as a potential pharmacological agent for its anti-inflammatory and analgesic effects, making it a candidate for the development of new drugs to treat various diseases.
Used in Research and Development:
8-Methylnaphthalene-1-carboxylic acid is utilized in research for its potential use in the development of new drugs, as it has been studied for its pharmacological properties and its role in the synthesis of other compounds with therapeutic potential.

Upstream product

• 518-86-5 1H,3H-benzo[de]isochromen-1-one 
• 5811-87-0 1,8-naphthalaldehydic acid 
• 861597-33-3 (8-carboxy-[1]naphthyl)-glyoxylic acid 
• 7732-18-5 water 
• 71739-32-7 2-acetylacenaphthenone 
• 160771-20-0 2-benzoylacenaphthenone 
• 81-84-5 1,8-Naphthalic anhydride 
• 110-05-4 di-tert-butyl peroxide 
• 86-55-5 1-naphthalenecarboxylic acid 
• 33500-78-6 ethyl 8-bromo-1-naphthoate 
• 1729-99-3 8-bromonaphthalene-1-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 10336-29-5 1-hydroxymethyl-8-methylnaphthalene 

Relevant academic research and scientific papers

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): (Formula (I)); where R1, and R2 are as described herein.

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1, and X2 are as described herein.

HCl/DMF for enhanced chemoselectivity in catalytic hydrogenolysis reactions

An improved, chemoselective hydrogenolysis method has been developed. By employing a solvent-acid combination (i.e., DMF-aq HCl) we were able to favor debenzylation rather than aromatic hydrogenation and acid-mediated bond cleavage which are the two main drawbacks of these reactions. The generality of the method, which was primarily developed as a solution to a carbohydrate problem, is shown by the successful hydrogenolysis of 1,8-naphthalide, a previously unsolved problem.

Triplet Ground States of 4-Substituted 1,8-Naphthoquinodimethanes

Photolysis of (5-substituted-8-methyl-1-naphthyl)diazomethanes in rigid glasses at 77 K leads to the triplet ESR spectra of the 4-substituted 1,8-naphthoquinodimethane biradicals.The substituents are X = H, Cl, Br, SPh, and SO2Ph.A study of the temperatur