10336-29-5

Basic information

• Product Name: 8-Methyl-1-naphthalenemethanol
• Synonyms: 8-Methyl-1-naphthalenemethanol;(8-Methylnaphthalen-1-yl)methanol
• CAS NO: 10336-29-5
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.22308
• Mol File: 10336-29-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 93-94.5 °C
• Boiling Point: 335.4±11.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• PKA: 14.38±0.10(Predicted)
• CAS DataBase Reference: 8-Methyl-1-naphthalenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methyl-1-naphthalenemethanol(10336-29-5)
• EPA Substance Registry System: 8-Methyl-1-naphthalenemethanol(10336-29-5)

Safety Data

• Hazardous Substances Data: 10336-29-5(Hazardous Substances Data)

Usage

General Description

8-Methyl-1-naphthalenemethanol is a synthetic chemical compound with the molecular formula C13H12O. It is an aromatic alcohol that belongs to the class of naphthalene derivatives and is used for various industrial applications. This chemical is commonly used as a raw material in the production of perfumes, fragrances, and flavors. It has a strong, floral odor and is often used in the formulation of personal care products and household cleaners. Additionally, 8-Methyl-1-naphthalenemethanol is used in the synthesis of other chemicals and is known for its antimicrobial properties, making it suitable for use in disinfectants and sanitizers. This chemical may pose health and safety risks if not handled and used properly, and precautions should be taken when working with it.

Upstream product

• 2026-08-6 naphthalene-1,8-diyldimethanol 
• 203-84-9 1H,3H-benzo[de]isochromene 
• 199988-50-6 (8-methoxymethyl-naphthalen-1-yl)-methanol 
• 19310-98-6 8-methyl-1-naphthoic acid 
• 81-84-5 1,8-Naphthalic anhydride 

Downstream Products

• 135734-04-2 1-(methoxymethyl)-8-methylnaphthalene 

Relevant articles and documents

Reductive cleavage of benzannelated cyclic ethers and amines: Synthetic applications

Reduction of symmetrical intramolecular diarylmethyl ethers (3a and 8a) and amines (3b and 8b) with alkali metals in THF allows the generation of unsymmetrical oxy- or amino-functionalised arylmethyl organometallics. Such intermediates were successfully trapped with various electrophiles, allowing a new access to unsymmetrically 2,2'-disubstituted-1,1'-biaryls (5aa-5bf) and 1,8-disubstituted naphthalenes (10aa-10be). (C) 2000 Elsevier Science Ltd.

New one-pot synthesis of a benzonorcaradiene derivative by reduction of naphthalic anhydride with LiAlH4

Reaction of naphthalic anhydride (naphthalene-1,8-dicarboxylic anhydride) (1) or of 1,8-bis(hydroxymethyl)naphthalene (3) with LiAlH4 in refluxing THF yields the benzonorcaradiene derivatives 2 in yields of up to 50%. It is proposed that in the formation of this (strained) product an anti-hydroalumination reaction is involved, which is facilitated by the assistance of a neighbouring alkoxide function.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Reductive opening of 1H,3H-benzo[de]isochromene: Synthesis of 1,8-difunctionalised naphthalenes

The lithiation of 1H,3H-benzo[de]isochromene (6) with lithium and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB, 5% molar) in THF at -50°C gives dianionic intermediate 7, which by reaction with different electrophiles {H2O, D2O, tBuCHO, PhCHO, Me 2CO, (CH3CH2)2CO, [CH 3(CH2)4]2CO, (CH2) 5CO, (CH2)7CO, (-)-menthone} at the same temperature followed by hydrolysis leads to functionalised alcohols 8. If after addition of a carbonyl compound as the first electrophile [tBuCHO, (CH2)5CO, (-)-menthone], the resulting dialcoholate 9 is allowed to react at 0°C, a second lithiation takes place to give intermediate 10 which by reaction with a second electrophile [H2O, tBuCHO, (CH2)5CO, CO2], yields, after hydrolysis, 1,8-difunctionalised naphthalenes 11. Cyclization under acidic conditions of diols 8e-i gives oxygen-containing eight-membered heterocycles, which are homologous to the starting material 6.