193202-41-4

Upstream product

• 26902-68-1 1,1,1-trifluorodecan-2-one 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 629-27-6 1-Iodooctane 
• 501037-00-9 1-benzenesulfonyl-2,2,2-trifluoro-ethanone O-benzyl-oxime 
• 622-33-3 N-benzyloxyamine 
• 501036-98-2 N-(benzyloxy)-2,2,2-trifluoroacetimidoyl chloride 
• 501036-99-3 N-benzyloxy-2,2,2-trifluoro-thioacetimidic acid phenyl ester 

Downstream Products

• 26902-68-1 1,1,1-trifluorodecan-2-one 

Relevant academic research and scientific papers

Radical-mediated synthesis of trifluoroethyl amines and trifluoromethyl ketones from alkyl iodides

Radical reaction of alkyl iodides with trifluoromethyl phenylsulfonyl oxime ether 10 and hexamethylditin at 300 nm in benzene afforded the corresponding trifluoromethyl oxime ethers 11 in high yields, which were reduced into the 2,2,2-trifluoroethyl amines with lithium aluminium hydride. The trifluoroethyl amines could be converted into the corresponding trifluoromethyl ketones by treatment with NBS and DBU.

A convenient preparative method for α-trifluoromethyl amines

α-Trifluoromethyl amines (IV) were prepared in three steps: preparation of α-trifluoromethyl ketones (I), their conversion to benzyloximes (II), and reduction of the oximes (II) with lithium aluminium hydride and sodium methoxide. For example, α-trifluoromethyltridecylamine was obtained from the reduction of trifluoromethyl dodecyl ketone benzyl oxime. Elsevier Science S.A.