193202-45-8

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 591-50-4 iodobenzene 
• 501037-00-9 1-benzenesulfonyl-2,2,2-trifluoro-ethanone O-benzyl-oxime 
• 622-33-3 N-benzyloxyamine 
• 501036-99-3 N-benzyloxy-2,2,2-trifluoro-thioacetimidic acid phenyl ester 
• 62-53-3 aniline 
• 501036-98-2 N-(benzyloxy)-2,2,2-trifluoroacetimidoyl chloride 

Downstream Products

• 51586-24-4 1-amino-2,2,2-trifluoro-1-phenylethane 

Relevant academic research and scientific papers

Metal-Free Transformation of Sulfonyl Oxime Ethers with Amines to Oxime Ethers

Sulfonyl oxime ethers undergo facile radical substitutions with various amines to yield the corresponding oxime ethers. An efficient arylation of sulfonyl oxime ethers was accomplished under ambient temperature and metal-free conditions, with a wide range of functional group tolerance. Mechanistic investigations indicate that a phenyl radical is involved in the catalytic cycle.

Radical-mediated synthesis of trifluoroethyl amines and trifluoromethyl ketones from alkyl iodides

Radical reaction of alkyl iodides with trifluoromethyl phenylsulfonyl oxime ether 10 and hexamethylditin at 300 nm in benzene afforded the corresponding trifluoromethyl oxime ethers 11 in high yields, which were reduced into the 2,2,2-trifluoroethyl amines with lithium aluminium hydride. The trifluoroethyl amines could be converted into the corresponding trifluoromethyl ketones by treatment with NBS and DBU.

A convenient preparative method for α-trifluoromethyl amines

α-Trifluoromethyl amines (IV) were prepared in three steps: preparation of α-trifluoromethyl ketones (I), their conversion to benzyloximes (II), and reduction of the oximes (II) with lithium aluminium hydride and sodium methoxide. For example, α-trifluoromethyltridecylamine was obtained from the reduction of trifluoromethyl dodecyl ketone benzyl oxime. Elsevier Science S.A.