193207-34-0

Usage

Uses

Used in Biochemistry:
Aspartic acid, N,N'-1,3-propanediylbisis used as a building block in the synthesis of complex biomolecules for research purposes. Its unique structure allows for the creation of novel compounds with potential applications in various biological systems.
Used in Pharmaceutical Industry:
Aspartic acid, N,N'-1,3-propanediylbisis used as a precursor in the development of new pharmaceutical compounds. Its ability to link with other molecules may contribute to the creation of innovative drugs with improved efficacy and reduced side effects.
Used in Materials Science:
Aspartic acid, N,N'-1,3-propanediylbisis used as a component in the development of advanced materials with specific properties. Its versatility in linking with other molecules can lead to the creation of materials with tailored characteristics for various applications.

Upstream product

• 109-76-2 Trimethylenediamine 
• 110-16-7 maleic acid 
• 110-17-8 (2E)-but-2-enedioic acid 

Relevant academic research and scientific papers

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-: N, N ′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

A series of aminocarboxylic acid analogues of aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) were chemoenzymatically synthesized via the addition of various mono- and diamine substrates to fumaric acid catalyzed by the enzyme EDDS lyase. Many of these novel AMA and EDDS analogues demonstrate potent inhibition of the bacterial metallo-β-lactamase NDM-1. Isothermal titration calorimetry assays revealed a strong correlation between the inhibitory potency of the compounds and their ability to bind zinc. Compounds 1a (AMA), 1b (AMB), 5 (EDDS), followed by 1d and 8a, demonstrate the highest synergy with meropenem resensitizing an NDM-1 producing strain of E. coli to this important carbapenem of last resort.