193269-79-3

Upstream product

• 1055268-63-7 (S)-tert-butyl 3-(2-bromoacetamido)pyrrolidin-1-carboxylate 
• 125552-56-9 (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 335280-33-6 tert-butyl (S)-3-(2-chloroacetamido)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

PROCESS FOR PRODUCING CARBAPENEM DERIVATIVE HAVING 1-ALKYLPYRROLIDINE STRUCTURE

It is an object of the invention to find a less expensive and highly safe synthetic route for carbapenem-type antibacterial agents suitable for large-scale synthesis. A production process for the preparation of carbapenem-type antibacterial agents: (Rsup