193275-28-4Relevant articles and documents
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs): Discovery of capromorelin
Carpino, Philip A.,Lefker, Bruce A.,Toler, Steven M.,Pan, Lydia C.,Hadcock, John R.,Cook, Ewell R.,DiBrino, Joseph N.,Campeta, Anthony M.,DeNinno, Shari L.,Chidsey-Frink, Kristin L.,Hada, William A.,Inthavongsay, John,Mangano, F. Michael,Mullins, Michelle A.,Nickerson, David F.,Ng, Oicheng,Pirie, Christine M.,Ragan, John A.,Rose, Colin R.,Tess, David A.,Wright, Ann S.,Yu, Li,Zawistoski, Michael P.,DaSilva-Jardine, Paul A.,Wilson, Theresa C.,Thompson, David D.
, p. 581 - 590 (2007/10/03)
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin (5, CP-424391-18, hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM) and the des-methyl an
