193286-94-1

Usage

Uses

Used in Pharmaceutical Synthesis:
Tert-Butyl (R)-a-AMino-cyclohexanepropanoate is utilized as a chiral building block for the creation of pharmaceuticals, leveraging its unique structural features to contribute to the development of complex molecules with specific biological activities.
Used in Organic Chemistry Research:
In the realm of organic chemistry, Tert-Butyl (R)-a-AMino-cyclohexanepropanoate serves as a key intermediate in the synthesis of various organic compounds, taking advantage of its sterically hindered and stereochemically rich structure to facilitate innovative chemical reactions and molecule constructions.
Used in Drug Development:
Tert-Butyl (R)-a-AMino-cyclohexanepropanoate is employed as a crucial component in drug development, where its versatility allows for the design and synthesis of new pharmaceutical agents with potential therapeutic applications, enhancing the repertoire of available treatments for various diseases and conditions.

Upstream product

• 58717-02-5 3-cyclohexyl-D-alanine 
• 115-11-7 isobutene 
• 3081-28-5 D-phenylalanine tert-butyl ester 
• 1218815-99-6 tert-butyl 3-cyclohexyl-2-oxopropanoate 
• 673-06-3 D-(R)-phenylalanine 

Downstream Products

• 193286-95-2 (R)-2-(Benzyloxycarbonylmethyl-amino)-3-cyclohexyl-propionic acid tert-butyl ester 
• 193287-01-3 C₅₂H₆₂N₆O₁₀ 
• 193286-96-3 (R)-2-(Benzyloxycarbonyl-benzyloxycarbonylmethyl-amino)-3-cyclohexyl-propionic acid tert-butyl ester 
• 193286-97-4 (R)-2-(Benzyloxycarbonyl-benzyloxycarbonylmethyl-amino)-3-cyclohexyl-propionic acid 

Relevant academic research and scientific papers

An efficient asymmetric biomimetic transamination of α-keto esters to chiral α-amino esters

An efficient asymmetric biomimetic transamination of α-keto esters with quinine derivatives as chiral bases was described. A wide variety of α-amino esters containing various functional groups can be synthesized in high yield and enantioselectivity.

An efficient preparation of the potent and selective pseudopeptide thrombin inhibitor, inogatran

Inogatran is an effective and selective pseudopeptide inhibitor of thrombin that has been shown to be efficacious in a series of in vitro and in vivo models of thrombosis. Herein, we report an efficient and convergent chemical synthesis of Inogatran that is amenable to the preparation of multiple gram quantities.

A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

The structural optimization for binding affinity and attempted modification of agonist function of a nonpeptide ligand of the human C5a receptor is described.