19338-12-6Relevant academic research and scientific papers
Carbon and Nitrogen Based Nanosheets as Fluorescent Probes with Tunable Emission
Sun, Jingwen,Malishev, Ravit,Azoulay, Adi,Tzadikov, Jonathan,Volokh, Michael,Jelinek, Raz,Shalom, Menny
, (2018)
2D carbon and nitrogen based semiconductors (CN) have attracted widespread attention for their possible use as low-cost and environmentally friendly materials for various applications. However, their limited solution-dispersibility and the difficulty in p
2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof
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Paragraph 0028-0029; 0058-0059, (2021/10/05)
The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.
Microwave-assisted clean synthesis of 6-aryl-2,4-diamino-1,3,5-triazines in [bmim][PF6]
Peng, Yanqing,Song, Gonghua
, p. 5313 - 5316 (2007/10/03)
An efficient and green approach was developed to prepare 6-aryl-2,4-diamino-1,3,5-triazines from corresponding arylnitriles and dicyanodiamide in ionic liquid [bmim][PF6] under computer-controlled microwave irradiation. Particularly valuable features of this method included the short reaction time, good yield, convenient operation and eco-friendly solvent.
Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions
Cooke,Augier de Cremiers,Rotello,Tarbit,Vanderstraeten
, p. 2787 - 2789 (2007/10/03)
The high yielding synthesis of 6-aryl-2,4-diaminopyrimidines and triazines via palladium catalysed Suzuki cross-coupling reactions of commercially available 6-chloro-2,4-diaminopyrimidine 1 or 6-chloro-2,4-diaminotriazine 8 and aryl boronic acids are desc
Model Systems for Flavoenzyme Activity. Regulation of Flavin Recognition via Modulation of Receptor Hydrogen-Bond Donor-Acceptor Properties
Deans, Robert,Cooke, Graeme,Rotello, Vincent M.
, p. 836 - 839 (2007/10/03)
We have synthesized a new family of receptors for flavins based on 6-aryl-2,4-(acyldiamino)-s-triazines. In these synthetic hosts, systematic variation of the spatially remote substituents on the 6-aryl ring alters the hydrogen-bond-donating abilities of the amide functionality and the hydrogen-bond-accepting properties of the triazine N(3). This variation results in a strong modulation of the efficiency of flavin binding, with association constants for the receptor flavin complexes ranging over an 8-fold range.
