3397-62-4Relevant articles and documents
Synthesis of DNA-Binding Peptoids
Mao, Jie,Bong, Dennis
, p. 1581 - 1585 (2015)
Programmable molecular recognition through nucleic acid base pairing has enabled applications in nano- and biotechnology using DNA, RNA, PNA, and more recently, bifacial PNA (bPNA). We describe herein the synthesis and DNA recognition properties of peptoid backbones bearing the bifacial synthetic nucleobase melamine. These 'peptoid nucleic acids' hybridize with thymine-rich DNA, like their peptide cognate (bPNA). DNA complexation is highly sensitive to peptoid side-chain length and overall charge. Peptoids isomeric with peptide bPNA were less efficient at DNA recognition, possibly due to conformational and steric differences. 1 Triazines and DNA Molecular Recognition 2 Synthesis of DNA-Binding Peptoids 3 Peptoid-DNA Binding Studies
SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY
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Paragraph 0364; 0367, (2020/11/12)
In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Synthesis, characterization and determination of HOMO-LUMO of the substituted 1,3,5-triazine molecule for the applications of organic electronics
Pakkath, Rajeesh,Eeda, Koti Reddy,Kuriakose, Sheena,Saritha,Sajith, Ayyiliath M.,Karuvalam, Ranjith Pakkath,Haridas, Karickal Raman
, p. 352 - 359 (2019/10/16)
The most important parameter of organic molecules for energy harvesting application focuses mainly on their band gap (HOMO-LUMO). In this report, we synthesized differently substituted 1,3,5-triazine based organic molecule which on future processing can be used in organic electronics like solar cells and OLED's. The energy gap of the synthesized novel analogue was calculated using cyclic voltammetry, UV-Visible spectroscopy and compared with density functional theory (DFT) studies.