19339-67-4

Upstream product

• 26040-23-3 N-phenyl-2-acetylbenzamide 
• 29879-72-9 2,3-dihydro-3-hydroxy-3-methyl-2-phenyl-1H-isoindolin-1-one 
• 28269-50-3 2-vinylbenzoic acid chloride 
• 27326-43-8 2-vinylbenzoic acid 
• 27326-46-1 N-phenyl-2-vinylbenzamide 
• 119-67-5 o-carboxybenzaldehyde 
• 62-53-3 aniline 
• 98-86-2 acetophenone 
• 1749-19-5 phenyl(1-phenylethylidene)amine 
• 13939-06-5 molybdenum hexacarbonyl 
• 201230-82-2 carbon monoxide 
• 41001-60-9 C₁₄H₁₂ClN 
• 520-03-6 N-phenylphthalimide 
• 118-92-3 anthranilic acid 

Downstream Products

• 128413-21-8 3'-(3-chlorophenyl)-2-phenylspiro<1H-isoindole-1,5'-(4'H)isoxazol>-3(2H)-one 
• 128413-22-9 2-phenyl-3'-<4-(trifluoromethyl)phenyl>spiro<1H-isoindole-1,5'(4'H)-isoxazol>-3(2H)-one 
• 128413-20-7 2-phenyl-3'-<3-(trifluoromethyl)phenyl>spiro<1H-isoindole-1,5'(4'H)-isoxazol>-3(2H)-one 
• 128413-18-3 2,3'-diphenylspiro<1H-isoindole-1,5'(4'H)-isoxazol>-3(2H)-one 

Relevant academic research and scientific papers

Synthesis of Isoindolinones through Intramolecular Amidation of ortho-Vinyl Benzamides

A synthetic approach of isoindolinones through intramolecular amidation of ortho-vinyl benzamides was reported. A variety of N-aryl isoindolinone derivatives were prepared in moderate to excellent yields using perfluorobutyl iodide as oxidant. (Figure pre

A Sulfone-Containing Imidazolium-Based Br?nsted Acid Ionic Liquid Catalyst Enables Replacing Dipolar Aprotic Solvents with Butyl Acetate

Replacing dipolar and aprotic solvents with environmentally benign media has emerged as a new facet of green chemistry. In this paper, a sulfone-containing imidazolium-based Br?nsted acid ionic liquid was prepared and used as a recyclable acid catalyst. The ionic liquid catalyst enables the use of an industrially acceptable and environmentally benign solvent, butyl acetate, as the reaction medium. The ionic liquid/butyl acetate biphasic system was successfully utilized in many organic reactions, which generally relied heavily on dipolar and aprotic solvents. (Figure presented.).

Palladium-Catalyzed Carbonylative Synthesis of 3-Methyleneisoindolin-1-ones from Ketimines with Hexacarbonylmolybdenum(0) as the Carbon Monoxide Source

An interesting procedure for the palladium-catalyzed carbonylative synthesis of 3-methyleneisoindolin-1-ones from ketimines was established. By using Mo(CO)6 (0.3 equiv.) as the solid CO source and through C(sp2)?H bond activation, t

Rhodium-Catalyzed Cyclocarbonylation of Ketimines via C-H Bond Activation

A novel rhodium-catalyzed oxidative cyclocarbonylation of ketimines via cleavage of two C-H bonds was established, which provided a direct and reliable method for the synthesis of a wide range of 3-methyleneisoindolin-1-ones with mostly moderate yields. P

Synthesis of 3-methyleneisoindolin-1-ones via palladium-catalyzed C-Cl bond cleavage and cyclocarbonylation of ortho-chloro ketimines

PdCl2(PCy3)2-catalyzed cyclocarbonylative coupling of ortho-chloro arylketimines with CO has been investigated to develop an efficient method for the synthesis of isoindolin-1-ones. The developed synthetic method has the a

Palladium-catalysed heteroannulation with terminal alkynes: A highly regio- and stereoselective synthesis of (Z)-3-aryl(alkyl)idene isoindolin-1- ones

A highly regio- and stereoselective method for the synthesis of (Z)-3- aryl(alkyl)idene isoindolin-1-ones through palladium-copper catalysis is described. 2-Iodobenzamide 1 and its substituted derivatives 2-10 were reacted with terminal alkynes 11-19 in the presence of (PPh3)2PdCl2, CuI, and Et3N in DMF mostly at 80°C for 16 h to yield the 2-alkynyl substituted benzamides 20-38, 40-45, 77 which could then be cyclised with NaOEt in EtOH to the 3-aryl(alkyl)idene isoindolin-1-ones 46-49, 51, 53-55, 57, 59-71, 73 and 75. In certain cases, the isoindolin-1-ones 50, 52, 56 and 58 could be directly obtained by the palladium-catalysed reactions. (C) 2000 Elsevier Science Ltd.

Preparation of 3-Hydroxyindolin-1-ones and o-Acylbenzamides. A Study of Ring-Chain Tautomerism

3-Hydroxyisoindolinones (ring form) as well as their chain tautomers, o-acylbenzamides, were prepared from the reactions of 3-benzalphthalide 1, 3-halophthalides 3, and o-acylbenzoic acids 6 or their esters 7 with amines 2, and those of phthalimides 4 wit

Spiroheterocycles from Reaction of Nitrile Oxides with 3-Methylenephthalimidines

In explorations of syntheses and chemistry of spiroheterocycles, we found that reaction of aromatic nitrile oxides with 3-methylenephthalimidines 8 produced spiroheterocycles 9.When N-benzyl-3-methylenephthalimidine (8c) was employed, oximes 10 and 11 wer

Reaction of 3-Hydroxyisoindolin-1-ones with Lawesson Reagent. Synthesis of Isoindoline-1-thiones

Treatment of 3-hydroxyisoindolin-1-ones 1 with Lawesson reagent gave isoindoline-1-thiones 2, by direct thionation and reductive elimination of hydroxy group, in good yields.

Benzylic Azide Functionalization of Tautomeric o-Acyl-benzoic Acid, -benzamide, and -nicotinic Acid Derivatives, and Thermal Decomposition of the Derived Azides

A series of benzylic azido compounds were prepared by the reactions of o-acyl-benzoic acids and -benzamides and pyridine analogues with sodium azide, diphenylphosphoryl azide, and trimethylsilyl azide.Thermal decomposition of the derived benzylic azides afforded three types of rearrangement products.The selectivity of rearrangement depended on the migratory aptitude of substituents and on stereoelectronic factors.