19340-82-0

Basic information

• Product Name: Propanamide, 3-hydroxy-N-(phenylmethyl)-
• CAS NO: 19340-82-0
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol File: 19340-82-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Propanamide, 3-hydroxy-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 3-hydroxy-N-(phenylmethyl)-(19340-82-0)
• EPA Substance Registry System: Propanamide, 3-hydroxy-N-(phenylmethyl)-(19340-82-0)

Safety Data

• Hazardous Substances Data: 19340-82-0(Hazardous Substances Data)

Upstream product

• 57-57-8 β-Propiolactone 
• 100-46-9 benzylamine 
• 38052-62-9 2-phenyl-[1,3]oxazinan-4-one 
• 119111-62-5 α-benzylaminocyclopropanecarboxylic acid 
• 19340-79-5 β-Benzyloxy-propionsaeure-benzylamid 
• 98-88-4 benzoyl chloride 
• 503-66-2 3-hydroxypropionic acid 
• 84098-45-3 3-hydroxypropionic acid isopropyl ester 
• 6149-41-3 methyl ester (3-hydroxy) propionic acid 
• 14273-92-8 methyl 5-hydroxypentanoate 

Downstream Products

• 67824-07-1 3-benzyl-2-octyl-[1,3]oxazinan-4-one 
• 67824-08-2 3-benzyl-2-nonyl-[1,3]oxazinan-4-one 
• 67824-05-9 3-benzyl-2-hexyl-[1,3]oxazinan-4-one 
• 67824-02-6 3-benzyl-2-butyl-[1,3]oxazinan-4-one 
• 67824-06-0 3-benzyl-2-heptyl-[1,3]oxazinan-4-one 
• 67824-09-3 3-benzyl-2-phenyl-1,3-oxazinan-4-one 
• 67823-99-8 3-benzyl-2-ethyl-[1,3]oxazinan-4-one 
• 67824-00-4 3-benzyl-2-propyl-[1,3]oxazinan-4-one 
• 19340-83-1 β-Phenylacetoxy-propionsaeure-benzylamid 
• 67824-03-7 3-benzyl-2-isobutyl-[1,3]oxazinan-4-one 
• 67824-01-5 3-benzyl-2-isopropyl-[1,3]oxazinan-4-one 
• 67824-04-8 3-benzyl-2-pentyl-[1,3]oxazinan-4-one 
• 67823-98-7 3-benzyl-2-methyl-[1,3]oxazinan-4-one 
• 67824-10-6 2,3-dibenzyl-[1,3]oxazinan-4-one 

Relevant articles and documents

CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

Reaction of Cyclopropanamines with Hypochlorite

Ethylene was formed in 65percent yield when 1-(1-piperidino)cyclopropanol 6, was treated with hypochlorite.This observation raised the possibility that 1-aminocyclopropanecarboxylic acids (ACCs) could yield ethylene by a mechanism that involves (1) decarboxylation to a 1-aminocyclopropanol, followed by (2) a fragmentation of the carbinolamine to ethylene induced by a hypochlorite equivalent.Although this mechanism could be ruled out only for 1e, no evidence could be found for it in the reactions of other ACCs, 1a-f, with hypochlorite.The fact that 1b-cis-2,3-d2 yieldedonly ethylene-cis-1,2-d2 is consistent with either the mechanism described above or a nitrenium ion mechanism.In the reaction of cyclopropanamines with neutral hypochlorite, ethylene is not the major product.From the primary and secondary amino acids 1a-c, a 3-hydroxypropanenitrile or propanamide, 2a-c, probably the product of a nucleophilic ring-opening step followed by decarboxylation, is formed.Similar products are formed from other cyclopropanamines: 2a from 1g, 2d from 1h, 2e and 2f from 1i, and lactone 5 from 1j.