193410-65-0Relevant academic research and scientific papers
Total synthesis of (S,S)-isodityrosine
Jung, Michael E.,Starkey, Laurie S.
, p. 8815 - 8824 (2007/10/03)
The novel dimeric amino acid isodityrosine I has been synthesized by a route which uses a new method of diaryl ether preparation. Nucleophilic addition of a protected tyrosine to cyclobexenone oxide and the Pd(0)- catalyzed coupling of an aryl iodide with a protected iodoalanine derivative are the key steps in this synthesis. This represents one of the first efficient syntheses of this molecule beginning with two naturally-occurring amino acids as inexpensive starting materials.
