193410-63-8

Upstream product

• 193410-61-6 methyl N-{[(1,1-dimethyl)ethoxy]carbonyl}-O-(6-oxo-1-cyclohexenyl)tyrosinate 
• 3978-80-1 Boc-Tyr-OH 
• 193410-62-7 methyl N-[(1,1-dimethylethoxy)carbonyl]-O-(5-chloro-6-oxo-1-cyclohexenyl)tyrosinate 
• 327621-01-2 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid 
• 327621-02-3 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester 

Downstream Products

• 193410-65-0 methyl N-[(1,1-dimethylethoxy)carbonyl]-O-[5-iodo-2-(phenylmethoxy)phenyl]tyrosinate 
• 327621-03-4 2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid methyl ester 
• 125873-94-1 (S,S)-isodityrosine bis hydrochloride 
• 193410-66-1 methyl N-[(1,1-dimethylethoxy)carbonyl]-O-[S]-[5-({[2-(1,1-dimethylethoxy)carbonyl]amino}-2-[(phenylmethoxy)carbonyl]ethyl)-2-(phenylmethoxy)phenyl]-L-tyrosinate 
• 327620-98-4 2-(R)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-iodopropionic acid methyl ester 
• 327621-04-5 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester 
• 327621-00-1 2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid 
• 192315-55-2 15-(S)-tert-butoxycarbonylamino-4-methoxy-12-(S)-(4-methoxybenzyl)-11,14-dioxo-2-oxa-10,13-diazatricyclo[15.2.2.1(3,7)]-docosa-1-⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-(S)-carboxylic acid methyl ester 
• 118493-33-7 (9S,12S,15S)-15-Acetylamino-4-methoxy-12-(4-methoxy-benzyl)-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester 
• 108890-90-0 K-13 

Relevant academic research and scientific papers

Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13

(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected

Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13

The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C

Total synthesis of (S,S)-isodityrosine

The novel dimeric amino acid isodityrosine I has been synthesized by a route which uses a new method of diaryl ether preparation. Nucleophilic addition of a protected tyrosine to cyclobexenone oxide and the Pd(0)- catalyzed coupling of an aryl iodide with a protected iodoalanine derivative are the key steps in this synthesis. This represents one of the first efficient syntheses of this molecule beginning with two naturally-occurring amino acids as inexpensive starting materials.