19345-87-0Relevant academic research and scientific papers
Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1
Pahari, Pallab,Saikia, Ujwal Pratim,Das, Trinath Prasad,Damodaran, Chendil,Rohr, Jürgen
supporting information, p. 3324 - 3334 (2016/05/19)
Synthetic scheme for the preparation of a number of different derivatives of anticancer natural product Psoralidin is described. A convergent synthetic approach is followed using simple starting materials like substituted phenyl acetic esters and benzoic acids. The developed synthetic route leads us to complete the first synthesis of an analogous natural product Lespeflorin I1, a mild melanin synthesis inhibitor. Preliminary bioactivity studies of the synthesized compounds are carried out against two commonly used prostate cancer cell lines. Results show that the bioactivity of the compounds can be manipulated by the simple modification of the functional groups.
Regioselective copper-catalyzed chlorination and bromination of arenes with O2 as the oxidant
Yang, Lujuan,Lu, Zhan,Stahl, Shannon S.
supporting information; experimental part, p. 6460 - 6462 (2010/03/04)
Electron-rich aromatic C-H bonds undergo regioselective chlorination and bromination in the presence of CuX2, LiX (X = Cl, Br) and molecular oxygen. Preliminary mechanistic insights suggest that the bromination and chlorination reactions proceed by different pathways.
