37715-47-2

Upstream product

• 57061-31-1 3-benzenesulfinyl-5H-furan-2-one 
• 126393-67-7 1,3-dimethoxy-1-trimethylsilyloxy-1,3-pentadiene 
• 308818-48-6 acetic acid 2-formyl-3,5-dimethoxy-6-methyl-benzyl ester 
• 108-59-8 malonic acid dimethyl ester 
• 239127-02-7 6-Iodo-5,7-dimethoxy-4-methylphthalide 
• 78-79-5 isoprene 
• 6652-32-0 3,5-dimethoxybenzylchloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 58137-76-1 4-bromo-5,7-dimethoxyphthalide 
• 99854-20-3 4-chloromethyl-5,7-dimethoxyphthalide 
• 58137-74-9 methyl 4,6-dimethoxy-3-bromo-2-(bromomethyl)benzoate 
• 130333-47-0 4,6-Dimethoxy-3-methylbenzocyclobuten-1(2H)-one 
• 130333-46-9 5-bromo-2, 4-dimethoxybenzaldehyde 

Downstream Products

• 27979-57-3 5,7-dihydroxy-4-methylphthalide 
• 24280-93-1 mycophenolic acid 

Relevant academic research and scientific papers

Synthetic study for two 2H-chromenic acids, 8-chlorocannabiorcichromenic acid and mycochromenic acid

Two 2H-chromenes having a fully substituted benzene ring, 8-chlorocannabioreichromene (1) and mycochromenic acid (2), were synthesized by a condensation of salicylaldehydes with isopropylidenemalonate or the thermal cyclization of corresponding propargyl ethers.

Syntheses of mycophenolic acid and its analogs by palladium methodology

Syntheses of mycophenolic acid (MPA, 1) and its analogs were carried out using palladium-catalyzed Heck carbonylation and olefination. Thus, the reaction of 2-bromo-3,5-dimethoxybenzyl alcohol (4) in toluene under carbon monoxide at 180 °C in the presence of palladium catalyst using sodium carbonate as a base gave 5,7-dimethoxyphthalide (5) in 88% yield. The phthalide 7 was converted to 6-iodo-5,7-dimethoxy-4-methylphthalide (8). Reaction of aromatic iodide 8 with isoprene and dimethyl malonate in the presence of palladium(0) catalyst gave the three component coupling product 9, which was converted into 1 in three steps. 4-NorMPA (16) and 4-homoMPA (22) were synthesized similarly.

An Efficient Synthesis of Dimethoxy Phthalides

This communication describes a convenient route for the synthesis of naturally occurring dimethoxy phthalides.

An improved synthesis of 5,7-dimethoxy-4-methyl-phthalide, a key intermediate in the synthesis of mycophenolic acid

An efficient synthetic pathway is described for 5,7-dimethoxy-4-methylphthalide, a key intermediate in the synthesis of mycophenolic acid and its analogues. The procedure starts from methyl 3,5-dimethoxybenzoate and involves five simple steps to give phth

The Oxidation of a Series of Phthalyl Alcohols

A series of phthalyl alcohols containing methoxy and methyl substituents were prepared by lithium aluminum hydride reduction of phthalides.Oxidation of the phthalyl alcohols with activated manganese dioxide or with barium manganate gave phthalaldehydes or