50625-55-3

Upstream product

• 124-38-9 carbon dioxide 
• 19345-87-0 1-Bromo-2,4-dimethoxy-5-methylbenzene 
• 24988-36-1 4,6-dibromo-1,3-dimethoxybenzene 
• 38064-90-3 2,4-dimethoxytoluene 
• 7149-91-9 2,4-dimethoxy-5-methyl-benzaldehyde 
• 93351-75-8 methyl 2,4-dimethoxy-5-methylbenzoate 

Downstream Products

• 864514-27-2 2-{(2R,3S)-5-[(2R,4R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-cyano-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-3-methyl-4-oxo-pentyl}-4,6-bis-(4-methoxy-benzyloxy)-3-methyl-benzoic acid methyl ester 
• 1402588-78-6 C₄₆H₅₃NO₁₀ 
• 1402588-83-3 C₄₁H₆₃NO₉Si₂ 
• 1402588-84-4 C₅₁H₈₃NO₁₂Si₂ 
• 1402589-26-7 C₅₁H₈₃NO₁₂Si₂ 
• 1402588-85-5 C₅₈H₈₇NO₁₃Si₂ 
• 1402588-86-6 C₅₀H₇₉NO₁₂Si₂ 
• 864514-28-3 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-(tert-butyl-dimethyl-silanyloxy)-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 
• 864514-30-7 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carboxylic acid amide 
• 864514-29-4 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carbonitrile 
• 864514-40-9 2-allyl-4,6-bis-(4-methoxy-benzyloxy)-3-methyl-benzoic acid methyl ester 
• 864514-17-0 4,6-bis-(4-methoxy-benzyloxy)-3-methyl-2-(2-oxo-ethyl)-benzoic acid methyl ester 
• 864514-21-6 2-allyl-N,N-diethyl-4,6-dimethoxy-3-methyl-benzamide 

Relevant academic research and scientific papers

Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1

Synthetic scheme for the preparation of a number of different derivatives of anticancer natural product Psoralidin is described. A convergent synthetic approach is followed using simple starting materials like substituted phenyl acetic esters and benzoic acids. The developed synthetic route leads us to complete the first synthesis of an analogous natural product Lespeflorin I1, a mild melanin synthesis inhibitor. Preliminary bioactivity studies of the synthesized compounds are carried out against two commonly used prostate cancer cell lines. Results show that the bioactivity of the compounds can be manipulated by the simple modification of the functional groups.

Studies toward the unique pederin family member psymberin: Full structure elucidation, two alternative total syntheses, and analogs

Two synthetic approaches to psymberin have been accomplished. A highly convergent first generation synthesis led to the complete stereochemical assignment and demonstrated that psymberin and irciniastatin A are identical compounds. This synthesis featured

Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds

The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: The invention further provides processes for making the compounds, their synthetic intermediates, and for me

Synthesis and complete stereochemical assignment of psymberin/irciniastatin A

We describe a concise and flexible synthetic avenue for the preparation of compounds with structures relevant to those proposed for the novel marine-derived differential cytotoxins psymberin and irciniastatin A. Our efforts led to their complete stereoche