19349-84-9Relevant academic research and scientific papers
Nucleophilic β-amination of pyridine nuclei
Nishiwaki, Nagatoshi,Nishida, Yutaka,Tominaga, Eiko,Ariga, Masahiro
, p. 4361 - 4363 (2007)
3-Bromo-4-nitropyridine N-oxide behaves as a useful substrate for causing nucleophilic substitution at the β-position (3-position) with amines to afford 3-aminopyridine derivatives.
Pyridine analogues of nimesulide: Design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors
Renard, Jean-Fran?ois,Arslan, Deniz,Garbacki, Nancy,Pirotte, Bernard,De Leval, Xavier
supporting information; experimental part, p. 5864 - 5871 (2010/02/28)
Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most prescribed medications, although the chronic use of such pharmacological agents is commonly associated with numerous side effects. The demonstration that the use of COX-2 selective or
Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors
Julémont, Fabien,De Leval, Xavier,Michaux, Catherine,Renard, Jean-Fran?ois,Winum, Jean-Yves,Montero, Jean-Louis,Damas, Jacques,Dogné, Jean-Michel,Pirotte, Bernard
, p. 6749 - 6759 (2007/10/03)
In this study, we report the synthesis and pharmacological evaluation of original pyridinic sulfonamides related to nimesulide, a cyclooxygenase-2 (COX-2) preferential inhibitor widely used as an anti-inflammatory agent. These original pyridinic derivativ
