19351-52-1Relevant academic research and scientific papers
An expedient three-component synthesis of tertiary benzylamines
Le Gall, Erwan,Decompte, Alexandre,Martens, Thierry,Troupel, Michel
experimental part, p. 249 - 254 (2010/04/05)
A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines. Georg Thieme Verlag Stuttgart.
Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines
Sengmany, Stéphane,Le Gall, Erwan,Le Jean, Cédric,Troupel, Michel,Nédélec, Jean-Yves
, p. 3672 - 3681 (2007/10/03)
Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes.
Direct Reductive Amination of Aldehydes and Ketones Using Phenylsilane: Catalysis by Dibutyltin Dichloride
Apodaca, Richard,Xiao, Wei
, p. 1745 - 1748 (2007/10/03)
(matrix presented) A procedure for direct reductive amination of aldehydes and ketones was developed which uses phenylsilane as a stoichiometric reductant and dibutyltin dichloride as a catalyst. Suitable amines included anilines and dialkylamines but not monoalkylamines.
