1935618-88-4Relevant academic research and scientific papers
COMBINATION PRODUCT FOR THE TREATMENT OF CANCEROUS DISEASES
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Page/Page column 125, (2021/12/31)
The present invention relates to a product for combination therapies useful for the treatment of cancer diseases. In particular, the invention relates to the combination of an anti-PD-Ll antibody and an MCT4 inhibitor of Formula (I). The therapeutic combination may be utilized for the use in treating a subject having a cancer disease that tests positive for PD-L1 and/or MCT4 expression.
DISUBSTITUTED ALKYNE DERIVATIVES
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Page/Page column 119, (2020/07/14)
The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.
Synthesis of 5-hydroxyquinolines
Li, Jianke,Kung, Daniel W.,Griffith, David A.
scheme or table, p. 3876 - 3878 (2010/08/19)
A series of 5-hydroxyquinolines has been prepared via the Skraup reaction. Several regioisomers were made either by selective displacement of a leaving group or by using a bromo substituent as a blocking group. The bromo group was found to be an excellent blocking group due to its stability during the Skraup reaction and easy removal thereafter. Halides at the 5-position of quinoline were found to be much more reactive than those at the 7- and 8-positions. Finally, we have also found a unique method to reduce the pyridyl ring on quinolines, leaving a halogen substituent untouched.
