193620-84-7Relevant academic research and scientific papers
Palladium-catalyzed one-pot approach to 3-(Diarylmethylene)oxindoles from propiolamidoaryl triflate
Lee, Dahye,Park, Sunhwa,Yu, Yoseb,Shin, Kye Jung,Seo, Jae Hong
, p. 14022 - 14032 (2015)
3-(Diarylmethylene)oxindoles have been synthesized from propiolamidoaryl triflate utilizing a palladium-catalyzed one-pot reaction consisting of three successive reactions: Sonogashira, Heck, and Suzuki-Miyaura. This method allows for the production of a complex skeleton of 3-(diarylmethylene)oxindole from propiolamidoaryl triflate using a commercially available aryl iodide and arylboronic acid in a simple and efficient way with moderate yield and stereoselectivity.
Consecutive one-pot versus domino multicomponent approaches to 3-(Diarylmethylene)oxindoles
Park, Sunhwa,Lee, Jiyun,Shin, Kye Jung,Oh, Euichaul,Seo, Jae Hong,Bunce, Richard A.
, (2017/04/03)
Based on consecutive one-pot conditions combining three palladium-catalyzed reactions (Sonogashira, Heck and Suzuki-Miyaura reactions), a more efficient domino multicomponent method has been successfully developed to access a wide variety of 3-(diarylmethylene)oxindoles. Microwave irradiation and use of a silver salt were the most important factors to achieve high yields and stereoselectivity.
Palladium-Catalyzed Tandem Approach to 3-(Diarylmethylene)oxindoles Using Microwave Irradiation
Park, Sunhwa,Shin, Kye Jung,Seo, Jae Hong
, p. 2296 - 2300 (2015/09/28)
We developed a rapid and efficient microwave-assisted tandem reaction for the synthesis of 3-(diarylmethylene)oxindoles. Three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions) were combined under microwave irradiation conditions to produce 3-(diarylmethylene)oxindoles from simple propiolamides, aryl iodides, and arylboronic acids. The addition of Ag3PO4 enhanced the yield and stereoselectivity of the tandem reaction significantly.
Synthesis of 3-(diarylmethylene)oxindoles via a palladium-catalyzed one-pot reaction: Sonogashira-heck-suzuki-miyaura combined reaction
Dong, Guang Ri,Park, Sunhwa,Lee, Dahye,Shin, Kye Jung,Seo, Jae Hong
supporting information, p. 1993 - 1997 (2013/09/24)
A novel one-pot reaction for the synthesis of 3-(diarylmethylene)oxindoles is described. The reaction involves the successive combination of three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki-Miyaura reactions). This method enables the rapid synthesis of various 3-(diarylmethylene)oxindoles from simple propiolamides. The addition of silver salts dramatically enhanced the E/Z stereoselectivity of the reaction. Georg Thieme Verlag Stuttgart, New York.
