19368-08-2

Basic information

• Product Name: 2''-CARBOXY-PHTHALANIC ACID
• Synonyms: 2''-CARBOXY-PHTHALANIC ACID;2-[(2-Carboxybenzoyl)amino]benzoic acid
• CAS NO: 19368-08-2
• Molecular Formula: C₁₅H₁₁NO₅
• Molecular Weight: 285.254
• Mol File: 19368-08-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2''-CARBOXY-PHTHALANIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2''-CARBOXY-PHTHALANIC ACID(19368-08-2)
• EPA Substance Registry System: 2''-CARBOXY-PHTHALANIC ACID(19368-08-2)

Safety Data

• Hazardous Substances Data: 19368-08-2(Hazardous Substances Data)

Upstream product

• 88-95-9 Phthaloyl dichloride 
• 118-92-3 anthranilic acid 
• 85-44-9 phthalic anhydride 
• 19795-35-8 2-(oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzoic acid 
• 41513-78-4 2-phthalimidobenzoic acid 
• 5766-76-7 2-benzylideneamino-benzoic acid 

Downstream Products

• 118-92-3 anthranilic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Relevant articles and documents

Inhibitory and Cooperative Effects Regulated by pH in Host-Guest Complexation between Cationic Pillar[5]arene and Reactive 2-Carboxyphthalanilic Acid

The study of host-guest complexation between reactive 2-carboxyphthalanilic acid (CPA) and two cationic pillararenes has been carried out. Host-guest complexation with significant kinetic effects was observed only with the smaller cavity size pillararene (P5A). Kinetics in the pH range 1.50-6.40, ESI-MS, 1H NMR titration, and ROESY experiments were performed to characterize the complexes. High binding stoichiometry (H:G2) was observed for all CPA protonation states. The system is pH-dependent, and inversion of cooperativity (negative to positive) occurs by increasing the dianionic CPA2- concentration (allosteric behavior). Toward physiological pH, association constant K1:1 does not change (104 M-1), and K1:2 increased from 102 to 104 M-1, as well as the inhibitory effect increased up to 222-fold. NMR results elucidated the structure of the complex and allowed us to create a map of H-H interactions that describes well the diversity and number of interactions in the complex. ?

Design, synthesis and anticancer activities evaluation of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units

Rucaparib and PJ34 were used as the structural model for the design of novel 5H-dibenzo[b,e]azepine-6,11-dione derivatives containing 1,3,4-oxadiazole units. And target compounds were successfully synthesized through a 3-step synthetic strategy. All target compounds were screened for their anti-proliferative effects against OVCAR-3 cell line. Preliminary biological study of these compounds provided potent compounds d21 and d22 with better activities than Rucaparib.

Compounds and methods for inducing chondrogenesis

The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.