19384-12-4Relevant academic research and scientific papers
Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents
Coppola, Gary M.,Damon, Robert E.,Eskesen, J. Bruce,France, Dennis S.,Paterniti Jr., James R.
, p. 113 - 117 (2007/10/03)
A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil (1). The optimal analogue 8d (HDL376) was shown to raise HDL choles
Design, Synthesis, and Biological Evaluation of Thio-Containing Compounds with Serum HDL-Cholesterol-Elevating Properties
Elokdah, Hassan,Sulkowski, Theodore S.,Abou-Gharbia, Magid,Butera, John A.,Chai, Sie-Yearl,McFarlane, Geraldine R.,McKean, Mar-Lee,Babiak, John L.,Adelman, Steven J.,Quinet, Elaine M.
, p. 681 - 695 (2007/10/03)
A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have HDL-elevating properties in several animal models. Concerns about the chemical and metabolic stability of 1
1,3-Disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis
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, (2008/06/13)
Antiatherosclerotic compounds of Formula I are provided: wherein: R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′; R′ is lower alkyl; n is an integer of 1-3; Ar is phenyl, or phenyl substituted with one or more of halogen, lower alkyl, alkenyl, alkynyl, alkoxy, perfluoroalkyl, perfluoroalkoxy, or alkylthio; and pharmaceutically acceptable salts thereof.
