Tetrahedron p. 2129 - 2142 (1998)
Update date:2022-08-03
Topics:
Micklefield, Jason
Fettes, Kevin J.
Dinucleotide analogues d(TnsnT) and d(TnsnA), in which the phosphodiester linkage of d(TpT) and d(TpA) is replaced by sulfamide [-NHSO2NH-], have been synthesised. Conformational analysis using 3J vicinal coupling constants shows that this modification results in a shift from a predominantly southern (C2'-endo) to northern (C3'-endo) ribose ring conformation. The effect of temperature and concentration changes on ribose conformation, reveals that the modified dinucleosides have a greater propensity to base stack intramolecularly, and in the case d(TnsnA), self-associate.
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