193894-21-2

Upstream product

• 25152-20-9 5'-amino-5'-deoxythymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1392513-45-9 C₂₆H₃₃N₃O₄Si 
• 19316-85-9 5'-azido-5'-deoxythymidine 
• 126441-74-5 3’-azido-5’-O-(4,4’-dimethoxytrityl)-3’-deoxythymidine 
• 132101-17-8 5′-azide-3′-O-tert-butyldimethylsilyl deoxythymidine 
• 193894-15-4 [(2S,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-sulfamic acid 2-hydroxy-phenyl ester 
• 193894-18-7 [(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester 
• 130128-70-0 5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine 
• 288391-04-8 4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate 
• 143526-94-7 3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine 
• 193894-17-6 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine 

Relevant academic research and scientific papers

LINKAGE MODIFIED OLIGOMERIC COMPOUNDS

The present invention provides gapped oligomeric compounds comprising from 1 to about 3 internucleoside linkages having one of formulas I to XVI. In certain embodiments, inclusion of from 1 to about 3 internucleoside linkages of one of formulas I to XVI,

Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups

Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential

Sulfamide replacement of the phosphodiester linkage in dinucleotides: Synthesis and conformational analysis

Dinucleotide analogues d(TnsnT) and d(TnsnA), in which the phosphodiester linkage of d(TpT) and d(TpA) is replaced by sulfamide [-NHSO2NH-], have been synthesised. Conformational analysis using 3J vicinal coupling constants shows that this modification results in a shift from a predominantly southern (C2'-endo) to northern (C3'-endo) ribose ring conformation. The effect of temperature and concentration changes on ribose conformation, reveals that the modified dinucleosides have a greater propensity to base stack intramolecularly, and in the case d(TnsnA), self-associate.

Synthesis of sulfamide linked dinucleotide analogues

Novel sulfamide [-NHSO2NH-] linked dinucleotide analogues d(TnsnT) and d(TnsnA) have been synthesised from 3'- and 5'-amino nucleosides. Treatment of these amino nucleosides with catechol sulfate results in the formation of 2-hydroxyphenyl sulf