19393-14-7

Upstream product

• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 
• 103-82-2 phenylacetic acid 
• 108-24-7 acetic anhydride 
• 552-89-6 2-nitro-benzaldehyde 
• 2082-59-9 pentanoic anhydride 
• 121-44-8 triethylamine 
• 114-70-5 sodium phenylacetate 
• 1555-80-2 phenylacetic anhydride 

Downstream Products

• 1022-66-8 3-phenyl-1,2,3,4-tetrahydro-2-quinolone 
• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 
• 71910-54-8 (E)-3-(2-Aminophenyl)-2-phenyl-2-propenoic acid 
• 35616-15-0 3c-(2-nitro-phenyl)-2-phenyl-acrylic acid amide 
• 871900-28-6 4-nitro-2-phenyl-inden-1-one 
• 51991-55-0 (Z)-3-(2-Hydroxyamino-phenyl)-2-phenyl-acrylic acid 
• 5328-96-1 α-Phenyl-o-aminozimtsaeure 
• 35616-15-0 3t-(2-nitro-phenyl)-2-phenyl-acrylic acid amide 

Relevant academic research and scientific papers

Synthesis of combretastatin analogs: Evaluation of in vitro anticancer activity and molecular docking studies

This study is based on the synthesis of a series of combretastatin analogs with different substitutions on one aryl moiety and a carboxylic group in connecting chain. Cis-configuration with respect to aryl groups was established by X-ray crystal analysis. All the synthesized compounds were evaluated for anticancer activity against a panel of cell lines. Six compounds 1a, 1b, 1c, 1k, 1n, and 1p showed marked anticancer activity against human colon (colo-205), lung (A549), ovary (IGROV-1), prostrate (PC-3), CNS (SF-295), leukemia (THP-1), and breast (MCF-7) cell lines. Out of these, 1b showed remarkable inhibitory activity comparable to paclitaxel against lung cancer cell line with IC50 3.9 μM. Importance of carboxylic group in the synthesized compounds was studied by flexible docking study of 1b which showed the importance of carboxylic group interactions with colchicine-binding site of ab-tubulin. Springer Science+Business Media, LLC 2011. Springer Science+Business Media, LLC 2011.